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Autologous bone marrow transplantation for acute lymphoblastic leukemia.

Publication ,  Journal Article
Doney, K; Buckner, CD; Fisher, L; Petersen, FB; Sanders, J; Appelbaum, FR; Anasetti, C; Badger, C; Bensinger, W; Deeg, HJ
Published in: Bone Marrow Transplant
October 1993

Between December 1979 and February 1991, 89 patients with ALL received autologous BMT. Median patient age was 18.4 years. Ten patients were in first remission, 52 were in second or greater remission and 27 were in relapse at the time of transplant. Conditioning regimens utilized chemotherapy alone (5 patients) or in combination with 10-15.75 Gy total body irradiation (84 patients). Disease-free survival at 1 year is 50% for patients transplanted in first remission, 27% for those in > or = second remission and 8% for patients in relapse. Pre- and post-transplant variables were evaluated in univariate and multivariate analyses for their effect on survival and relapse. Factors significantly associated with improved survival were being transplanted in first remission and achieving a self-sustained platelet count > or = 20 x 10(9)/l in a shorter period of time. A decreased relapse rate after transplant was associated with a lower white blood count at diagnosis, being transplanted in first remission and not being transplanted in relapse.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

October 1993

Volume

12

Issue

4

Start / End Page

315 / 321

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Survival Rate
  • Salvage Therapy
  • Risk
  • Retrospective Studies
  • Remission Induction
  • Prognosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Middle Aged
 

Citation

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Doney, K., Buckner, C. D., Fisher, L., Petersen, F. B., Sanders, J., Appelbaum, F. R., … Deeg, H. J. (1993). Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant, 12(4), 315–321.
Doney, K., C. D. Buckner, L. Fisher, F. B. Petersen, J. Sanders, F. R. Appelbaum, C. Anasetti, C. Badger, W. Bensinger, and H. J. Deeg. “Autologous bone marrow transplantation for acute lymphoblastic leukemia.Bone Marrow Transplant 12, no. 4 (October 1993): 315–21.
Doney K, Buckner CD, Fisher L, Petersen FB, Sanders J, Appelbaum FR, et al. Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant. 1993 Oct;12(4):315–21.
Doney, K., et al. “Autologous bone marrow transplantation for acute lymphoblastic leukemia.Bone Marrow Transplant, vol. 12, no. 4, Oct. 1993, pp. 315–21.
Doney K, Buckner CD, Fisher L, Petersen FB, Sanders J, Appelbaum FR, Anasetti C, Badger C, Bensinger W, Deeg HJ. Autologous bone marrow transplantation for acute lymphoblastic leukemia. Bone Marrow Transplant. 1993 Oct;12(4):315–321.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

October 1993

Volume

12

Issue

4

Start / End Page

315 / 321

Location

England

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Survival Rate
  • Salvage Therapy
  • Risk
  • Retrospective Studies
  • Remission Induction
  • Prognosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Middle Aged