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Gynecological abnormalities following allogeneic bone marrow transplantation.

Publication ,  Journal Article
Schubert, MA; Sullivan, KM; Schubert, MM; Nims, J; Hansen, M; Sanders, JE; O'Quigley, J; Witherspoon, RP; Buckner, CD; Storb, R
Published in: Bone Marrow Transplant
June 1990

Forty-four post-pubertal women were studied 261-4628 days after allogeneic transplantation to determine the nature and degree of gynecological abnormalities following bone marrow transplantation. Evaluations included pelvic examinations, exfoliative cytology, serum gonadotropin levels, direct preparations for micro-organisms, and microbial cultures. Pelvic abnormalities were detected in 35 of 44 (80%) women and resembled atrophic changes known to occur after ovarian failure. Findings included reduced vaginal elasticity and rugal folds, pale tissues, small vaginal, uterine and cervical size, atrophic vulvovaginitis, introital stenosis, and loss of pubic hair. Atrophic abnormalities were noted in 33 of 36 recipients of total body irradiation (TBI) compared to two of eight women not prepared with TBI (p = 0.02). Vasomotor symptoms were reported in 67% of TBI recipients compared to 38% of those not given TBI. Elevated serum gonadotropin levels suggested that TBI had caused the ovarian failure. Recognition of these gynecological abnormalities can lead to earlier hormone replacement, alleviating unnecessary discomfort and improving the well-being of the marrow transplant recipient.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

June 1990

Volume

5

Issue

6

Start / End Page

425 / 430

Location

England

Related Subject Headings

  • Vagina
  • Uterus
  • Transplantation, Homologous
  • Immunology
  • Humans
  • Genital Diseases, Female
  • Follow-Up Studies
  • Female
  • Cervix Uteri
  • Bone Marrow Transplantation
 

Citation

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Chicago
ICMJE
MLA
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Schubert, M. A., Sullivan, K. M., Schubert, M. M., Nims, J., Hansen, M., Sanders, J. E., … Storb, R. (1990). Gynecological abnormalities following allogeneic bone marrow transplantation. Bone Marrow Transplant, 5(6), 425–430.
Schubert, M. A., K. M. Sullivan, M. M. Schubert, J. Nims, M. Hansen, J. E. Sanders, J. O’Quigley, R. P. Witherspoon, C. D. Buckner, and R. Storb. “Gynecological abnormalities following allogeneic bone marrow transplantation.Bone Marrow Transplant 5, no. 6 (June 1990): 425–30.
Schubert MA, Sullivan KM, Schubert MM, Nims J, Hansen M, Sanders JE, et al. Gynecological abnormalities following allogeneic bone marrow transplantation. Bone Marrow Transplant. 1990 Jun;5(6):425–30.
Schubert, M. A., et al. “Gynecological abnormalities following allogeneic bone marrow transplantation.Bone Marrow Transplant, vol. 5, no. 6, June 1990, pp. 425–30.
Schubert MA, Sullivan KM, Schubert MM, Nims J, Hansen M, Sanders JE, O’Quigley J, Witherspoon RP, Buckner CD, Storb R. Gynecological abnormalities following allogeneic bone marrow transplantation. Bone Marrow Transplant. 1990 Jun;5(6):425–430.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

June 1990

Volume

5

Issue

6

Start / End Page

425 / 430

Location

England

Related Subject Headings

  • Vagina
  • Uterus
  • Transplantation, Homologous
  • Immunology
  • Humans
  • Genital Diseases, Female
  • Follow-Up Studies
  • Female
  • Cervix Uteri
  • Bone Marrow Transplantation