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Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience

Publication ,  Journal Article
Buckner, CD; Fefer, A; Bensinger, WI; Storb, R; Durie, BG; Appelbaum, FR; Petersen, FB; Weiden, P; Clift, RA; Sanders, JE; Sullivan, KM ...
Published in: European Journal of Haematology, Supplement
1989

28 patients with plasma cell malignancies received marrow transplants from identical twins(N = 8), HLA-identical family members (N = 15), HLA partially-matched relatives (N = 3) or cryopreserved autologous marrow (N = 2). Treatment regimens included cyclophosphamide (CY) and total body irradiation (TBI) for 15 patients and busulphan (BU) and CY for 13 ptients. 3 of 8 twins are alive, 2 without disease at 24 and 34 months, and 1 is alive and well at 116 months without evidence of disease except for at small residual monoclonal protein spike. 12 of 18 allografted patients died of transplant-related causes and 2 died of progressive disease. 4 of 18 allograft receipients are alive; 2 are free of disease at 16 and 15 monthsm 1 is alive at 6 months without disease except for persistent monoclonal Kappa protein. 1 patient is alive with residual marrow involvement and a persistent IGA lambda monoclonal protein at 7 months. 1 of the 2 autograft recipients is alive 2 months after transplant and is not yet evaluable for tumor response and the other patient died early of transplant-related complications. Both CY + TBI and BU + CY resulted in remissions in patients with advanced plasma cell malignancies. However, the optimal treatment regimen and timing of transplantation remain to be determined.

Duke Scholars

Published In

European Journal of Haematology, Supplement

Publication Date

1989

Volume

43

Issue

51

Start / End Page

186 / 190

Related Subject Headings

  • Oncology & Carcinogenesis
 

Citation

APA
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ICMJE
MLA
NLM
Buckner, C. D., Fefer, A., Bensinger, W. I., Storb, R., Durie, B. G., Appelbaum, F. R., … Thomas, E. D. (1989). Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience. European Journal of Haematology, Supplement, 43(51), 186–190.
Buckner, C. D., A. Fefer, W. I. Bensinger, R. Storb, B. G. Durie, F. R. Appelbaum, F. B. Petersen, et al. “Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience.” European Journal of Haematology, Supplement 43, no. 51 (1989): 186–90.
Buckner CD, Fefer A, Bensinger WI, Storb R, Durie BG, Appelbaum FR, et al. Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience. European Journal of Haematology, Supplement. 1989;43(51):186–90.
Buckner, C. D., et al. “Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience.” European Journal of Haematology, Supplement, vol. 43, no. 51, 1989, pp. 186–90.
Buckner CD, Fefer A, Bensinger WI, Storb R, Durie BG, Appelbaum FR, Petersen FB, Weiden P, Clift RA, Sanders JE, Sullivan KM, Witherspoon RP, Hill R, Martin P, Thomas ED. Marrow transplantation for malignant plasma cell disorders: Summary of the Seattle experience. European Journal of Haematology, Supplement. 1989;43(51):186–190.

Published In

European Journal of Haematology, Supplement

Publication Date

1989

Volume

43

Issue

51

Start / End Page

186 / 190

Related Subject Headings

  • Oncology & Carcinogenesis