Skip to main content

Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study.

Publication ,  Journal Article
Petersen, FB; Buckner, CD; Appelbaum, FR; Clift, RA; Sanders, JE; Bensinger, WI; Storb, R; Witherspoon, RP; Sullivan, KM; Bearman, SI
Published in: Bone Marrow Transplant
November 1989

Thirty-six patients with advanced hematologic malignancy were entered into a phase I study designed to define a tolerable dose of busulfan (BU) and cyclophosphamide (CY) combined with 12 Gy of fractionated total body irradiation (TBI) as preparation for marrow transplantation from HLA-identical siblings, 0-1 locus HLA-non-identical family members or autologous cryopreserved marrow. Five of 18 evaluable patients prepared with 8.7 mg/kg of BU and 69 mg/kg CY + TBI developed severe regimen related toxicity (RRT) while none of 15 patients treated with 6.9 mg/kg of BU and 47 mg/kg of CY + TBI developed severe RRT. Ten of the 15 evaluable patients treated on the lower dose level are alive, nine disease-free, 262-737 days (median, 547) post-transplant with a 87% and 67% actuarial probability of survival at 3 and 18 months respectively. Six of the 18 patients treated on the higher dose level are alive disease-free 273-1039 days (median, 668) post-transplant with a 56% and 27% actuarial probability of survival at 3 and 18 months respectively. Eighteen patients were transplanted with allogeneic marrow for chronic myelogenous leukemia beyond chronic phase and acute non-lymphocytic leukemia beyond first remission or in relapse other than first untreated relapse and only one has relapsed posttransplant. It was concluded that a transplant preparative regimen combining 6.9 mg/kg of BU with 47 mg/kg of CY followed by 12 Gy fractionated TBI is well tolerated. The high probability of surviving this regimen and the low early relapse rate in patients with advanced myeloid malignancies is encouraging.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

November 1989

Volume

4

Issue

6

Start / End Page

617 / 623

Location

England

Related Subject Headings

  • Whole-Body Irradiation
  • Survival Analysis
  • Prospective Studies
  • Middle Aged
  • Lymphoma
  • Leukemia
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Drug Evaluation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Petersen, F. B., Buckner, C. D., Appelbaum, F. R., Clift, R. A., Sanders, J. E., Bensinger, W. I., … Bearman, S. I. (1989). Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study. Bone Marrow Transplant, 4(6), 617–623.
Petersen, F. B., C. D. Buckner, F. R. Appelbaum, R. A. Clift, J. E. Sanders, W. I. Bensinger, R. Storb, R. P. Witherspoon, K. M. Sullivan, and S. I. Bearman. “Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study.Bone Marrow Transplant 4, no. 6 (November 1989): 617–23.
Petersen FB, Buckner CD, Appelbaum FR, Clift RA, Sanders JE, Bensinger WI, et al. Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study. Bone Marrow Transplant. 1989 Nov;4(6):617–23.
Petersen FB, Buckner CD, Appelbaum FR, Clift RA, Sanders JE, Bensinger WI, Storb R, Witherspoon RP, Sullivan KM, Bearman SI. Busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for marrow transplantation in patients with advanced hematological malignancies: a phase I study. Bone Marrow Transplant. 1989 Nov;4(6):617–623.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

November 1989

Volume

4

Issue

6

Start / End Page

617 / 623

Location

England

Related Subject Headings

  • Whole-Body Irradiation
  • Survival Analysis
  • Prospective Studies
  • Middle Aged
  • Lymphoma
  • Leukemia
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Drug Evaluation