Scholars@Duke publication: Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants

Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants

Publication , Journal Article

Emanuel, RL; Torday, JS; Asokananthan, N; Sunday, ME

Published in: Peptides

2001

Fetal lung produces corticotropin-releasing hormone (CRH) without known direct effects. We tested the hypothesis that CRH can directly regulate lung development. In baboon fetal lung explants, CRH strongly induces surfactant phospholipid synthesis and SP-C immunostaining, plus [3H]thymidine incorporation. CRH receptor mRNA was detected in lung from multiple baboons at e125. Testing thyrotropin (TRH) as a specificity control, we did demonstrate different direct effects with only modest stimulation of surfactant phospholipid synthesis and strong induction of cytidylyltransferase gene expression. Therefore, CRH, similar to ACTH and glucocorticoids, is a potent inducer of cell differentiation in fetal lung. © 2000 Published by Elsevier Science Inc.

Duke Scholars

Author Mary Elizabeth Anne Sunday Pathology

Published In

Peptides

Publication Date

2001

Volume

Issue

Start / End Page

1819 / 1829

Related Subject Headings

Endocrinology & Metabolism
1115 Pharmacology and Pharmaceutical Sciences
0606 Physiology
0304 Medicinal and Biomolecular Chemistry

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Emanuel, R. L., Torday, J. S., Asokananthan, N., & Sunday, M. E. (2001). Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides, 22(12), 1819–1829.

Emanuel, R. L., J. S. Torday, N. Asokananthan, and M. E. Sunday. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.” Peptides 22, no. 12 (2001): 1819–29.

Emanuel RL, Torday JS, Asokananthan N, Sunday ME. Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides. 2001;22(12):1819–29.

Emanuel, R. L., et al. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.” Peptides, vol. 22, no. 12, 2001, pp. 1819–29.

Emanuel RL, Torday JS, Asokananthan N, Sunday ME. Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides. 2001;22(12):1819–1829.