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Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19.

Publication ,  Journal Article
Submacular Surgery Trials Research Group,
Published in: Ophthalmic Epidemiol
2007

PURPOSE: To evaluate responsiveness of the National Eye Institute Visual Function Questionnaire (NEI-VFQ) to changes in visual acuity and to provide estimates of minimum clinically meaningful changes in NEI-VFQ scores. METHODS: Data were combined from three clinical trials of submacular surgery for subfoveal choroidal neovascularization. Patients who completed NEI-VFQ interviews and visual acuity measurements at baseline and 2 years later contributed data for analysis. Data were analyzed using anchor-based (relating 2-year change in NEI-VFQ to 2-year change in visual acuity using correlation and linear regression) and distribution-based (standardized response mean) methods. RESULTS: Of 1,015 patients enrolled, 828 patients completed NEI-VFQ interviews and had visual acuity measurements at baseline and 2 years later. Median age of patients was 75 years (range 18 to 94); all patients had subfoveal choroidal neovascularization in at least one eye. Median overall NEI-VFQ score at baseline was 69.9 (mean, 66.5). Based on anchor-based methods, a 2-line change in visual acuity of the better-seeing eye translated to a 3.4-point change in the overall NEI-VFQ score and from 2.4-point to 7.0-point changes in most subscale scores. The NEI-VFQ was sensitive to both gains and losses in visual acuity; the standardized response mean for the overall NEI-VFQ score in patients with a 2-line gain was 0.6 and for patients with 2-line loss was -0.3. In the subgroup of patients with a 2-line loss of visual acuity in the better-seeing eye, patients who had overall NEI-VFQ scores at baseline greater than the median (59.8) had an standardized response mean of -0.9 for the overall NEI-VFQ score and patients who had overall NEI-VFQ scores at baseline at or below the median had a standardized response mean of 0.2 for the overall NEI-VFQ score. A 4-point change in the overall NEI-VFQ and a 5-point change in individual subscale scores corresponded to a small clinically meaningful change. CONCLUSIONS: The NEI-VFQ was responsive to 2-year changes in visual acuity but was less responsive to changes among patients with poorer NEI-VFQ scores at baseline. Based on this analysis, a 4-point change in the overall NEI-VFQ and a 5-point change in individual subscale scores may be considered minimum clinically meaningful within-person changes in NEI-VFQ scores.

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Published In

Ophthalmic Epidemiol

DOI

ISSN

0928-6586

Publication Date

2007

Volume

14

Issue

4

Start / End Page

205 / 215

Location

England

Related Subject Headings

  • Visual Acuity
  • United States
  • Surveys and Questionnaires
  • Sickness Impact Profile
  • Quality of Life
  • Ophthalmology
  • National Institutes of Health (U.S.)
  • Middle Aged
  • Male
  • Macular Degeneration
 

Citation

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Submacular Surgery Trials Research Group, . (2007). Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19. Ophthalmic Epidemiol, 14(4), 205–215. https://doi.org/10.1080/09286580701502970
Submacular Surgery Trials Research Group, Takeo. “Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19.Ophthalmic Epidemiol 14, no. 4 (2007): 205–15. https://doi.org/10.1080/09286580701502970.
Submacular Surgery Trials Research Group, Takeo. “Evaluation of minimum clinically meaningful changes in scores on the National Eye Institute Visual Function Questionnaire (NEI-VFQ) SST Report Number 19.Ophthalmic Epidemiol, vol. 14, no. 4, 2007, pp. 205–15. Pubmed, doi:10.1080/09286580701502970.
Journal cover image

Published In

Ophthalmic Epidemiol

DOI

ISSN

0928-6586

Publication Date

2007

Volume

14

Issue

4

Start / End Page

205 / 215

Location

England

Related Subject Headings

  • Visual Acuity
  • United States
  • Surveys and Questionnaires
  • Sickness Impact Profile
  • Quality of Life
  • Ophthalmology
  • National Institutes of Health (U.S.)
  • Middle Aged
  • Male
  • Macular Degeneration