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Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation.

Publication ,  Journal Article
Hutson, KA; Durham, D; Imig, T; Tucci, DL
Published in: Hear Res
March 2008

The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in postnatal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected with 2-DG and exposed to an alternating auditory stimulus (1 and 2kHz tones). Uptake of 2-DG was measured in the inferior colliculus (IC), medial geniculate (MG), and auditory cortex (fields AI and AAF) of both sides of the brain in experimental animals and in anesthesia-only sham animals (SH). Significant differences in uptake, compared to SH, were found in the IC contralateral to the manipulated ear (CHL or CA) and in AAF contralateral to the CHL ear. We hypothesize that these findings may result from loss of functional inhibition in the IC contralateral to CA, but not CHL. Altered states of inhibition at the IC may affect activity in pathways ascending to auditory cortex, and ultimately activity in auditory cortex itself. Altered levels of activity in auditory cortex may explain some auditory processing deficits experienced by individuals with CHL.

Duke Scholars

Published In

Hear Res

DOI

ISSN

0378-5955

Publication Date

March 2008

Volume

237

Issue

1-2

Start / End Page

19 / 31

Location

Netherlands

Related Subject Headings

  • Otorhinolaryngology
  • Inferior Colliculi
  • Hearing Loss, Unilateral
  • Hearing Loss, Conductive
  • Gerbillinae
  • Geniculate Bodies
  • Disease Models, Animal
  • Deoxyglucose
  • Denervation
  • Cochlea
 

Citation

APA
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ICMJE
MLA
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Hutson, K. A., Durham, D., Imig, T., & Tucci, D. L. (2008). Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation. Hear Res, 237(1–2), 19–31. https://doi.org/10.1016/j.heares.2007.12.007
Hutson, K. A., D. Durham, T. Imig, and D. L. Tucci. “Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation.Hear Res 237, no. 1–2 (March 2008): 19–31. https://doi.org/10.1016/j.heares.2007.12.007.
Hutson KA, Durham D, Imig T, Tucci DL. Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation. Hear Res. 2008 Mar;237(1–2):19–31.
Hutson, K. A., et al. “Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation.Hear Res, vol. 237, no. 1–2, Mar. 2008, pp. 19–31. Pubmed, doi:10.1016/j.heares.2007.12.007.
Hutson KA, Durham D, Imig T, Tucci DL. Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation. Hear Res. 2008 Mar;237(1–2):19–31.
Journal cover image

Published In

Hear Res

DOI

ISSN

0378-5955

Publication Date

March 2008

Volume

237

Issue

1-2

Start / End Page

19 / 31

Location

Netherlands

Related Subject Headings

  • Otorhinolaryngology
  • Inferior Colliculi
  • Hearing Loss, Unilateral
  • Hearing Loss, Conductive
  • Gerbillinae
  • Geniculate Bodies
  • Disease Models, Animal
  • Deoxyglucose
  • Denervation
  • Cochlea