Skip to main content

Emerging roles for lipid droplets in immunity and host-pathogen interactions.

Publication ,  Journal Article
Saka, HA; Valdivia, R
Published in: Annu Rev Cell Dev Biol
2012

Lipid droplets (LDs) are neutral lipid storage organelles ubiquitous to eukaryotic cells. It is increasingly recognized that LDs interact extensively with other organelles and that they perform functions beyond passive lipid storage and lipid homeostasis. One emerging function for LDs is the coordination of immune responses, as these organelles participate in the generation of prostaglandins and leukotrienes, which are important inflammation mediators. Similarly, LDs are also beginning to be recognized as playing a role in interferon responses and in antigen cross presentation. Not surprisingly, there is emerging evidence that many pathogens, including hepatitis C and Dengue viruses, Chlamydia, and Mycobacterium, target LDs during infection either for nutritional purposes or as part of an anti-immunity strategy. We here review recent findings that link LDs to the regulation and execution of immune responses in the context of host-pathogen interactions.

Duke Scholars

Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

2012

Volume

28

Start / End Page

411 / 437

Location

United States

Related Subject Headings

  • Virus Assembly
  • Organelles
  • Lipids
  • Lipid Metabolism
  • Humans
  • Host-Pathogen Interactions
  • Hepatitis C
  • Hepacivirus
  • Developmental Biology
  • Bacterial Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Saka, H. A., & Valdivia, R. (2012). Emerging roles for lipid droplets in immunity and host-pathogen interactions. Annu Rev Cell Dev Biol, 28, 411–437. https://doi.org/10.1146/annurev-cellbio-092910-153958

Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

2012

Volume

28

Start / End Page

411 / 437

Location

United States

Related Subject Headings

  • Virus Assembly
  • Organelles
  • Lipids
  • Lipid Metabolism
  • Humans
  • Host-Pathogen Interactions
  • Hepatitis C
  • Hepacivirus
  • Developmental Biology
  • Bacterial Infections