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Multiplexing superparamagnetic beads driven by multi-frequency ratchets.

Publication ,  Journal Article
Gao, L; Tahir, MA; Virgin, LN; Yellen, BB
Published in: Lab on a chip
December 2011

Here, we explore the single particle dynamics of superparamagnetic beads exposed to multifrequency ratchets. Through a combination of theory, simulation, and experiment, we determine the important tuning parameters that can be used to implement multiplexed separation of polydisperse colloidal mixtures. In particular, our results demonstrate that the ratio of driving frequencies controls the transition between open and closed trajectories that allow particles to be transported across a substrate. We also demonstrate that the phase difference between the two frequencies controls not only the direction of motion but also which particles are allowed to move within a polydisperse mixture. These results represent a fundamentally different approach to colloidal separation than the previous methods which are based on controlling transitions between phase-locked and phase-slipping regimes, and have a higher degree of multiplexing capabilities that can benefit the fields of biological separation and sensing as well as provide crucial insights into general ratchet behavior.

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Published In

Lab on a chip

DOI

EISSN

1473-0189

ISSN

1473-0197

Publication Date

December 2011

Volume

11

Issue

24

Start / End Page

4214 / 4220

Related Subject Headings

  • Nonlinear Dynamics
  • Miniaturization
  • Microspheres
  • Magnetics
  • Colloids
  • Analytical Chemistry
  • Algorithms
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
 

Citation

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Gao, L., Tahir, M. A., Virgin, L. N., & Yellen, B. B. (2011). Multiplexing superparamagnetic beads driven by multi-frequency ratchets. Lab on a Chip, 11(24), 4214–4220. https://doi.org/10.1039/c1lc20683d
Gao, Lu, Mukarram A. Tahir, Lawrence N. Virgin, and Benjamin B. Yellen. “Multiplexing superparamagnetic beads driven by multi-frequency ratchets.Lab on a Chip 11, no. 24 (December 2011): 4214–20. https://doi.org/10.1039/c1lc20683d.
Gao L, Tahir MA, Virgin LN, Yellen BB. Multiplexing superparamagnetic beads driven by multi-frequency ratchets. Lab on a chip. 2011 Dec;11(24):4214–20.
Gao, Lu, et al. “Multiplexing superparamagnetic beads driven by multi-frequency ratchets.Lab on a Chip, vol. 11, no. 24, Dec. 2011, pp. 4214–20. Epmc, doi:10.1039/c1lc20683d.
Gao L, Tahir MA, Virgin LN, Yellen BB. Multiplexing superparamagnetic beads driven by multi-frequency ratchets. Lab on a chip. 2011 Dec;11(24):4214–4220.
Journal cover image

Published In

Lab on a chip

DOI

EISSN

1473-0189

ISSN

1473-0197

Publication Date

December 2011

Volume

11

Issue

24

Start / End Page

4214 / 4220

Related Subject Headings

  • Nonlinear Dynamics
  • Miniaturization
  • Microspheres
  • Magnetics
  • Colloids
  • Analytical Chemistry
  • Algorithms
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering