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DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies.

Publication ,  Journal Article
Uziel, M; Munro, NB; Katz, DS; Vo-Dinh, T; Zeighami, EA; Waters, MD; Griffith, JD
Published in: Mutation research
July 1992

DNA adduct formation, route of absorption, metabolism and chemistry of 12 hazardous chemicals are reviewed. Methods for adduct detection are also reviewed and approaches to sensitivity and specificity are identified. The selection of these 12 chemicals from the Environmental Protection Agency list of genotoxic chemicals was based on the availability of information and on the availability of populations potentially suitable for molecular epidemiological study. The 12 chemicals include ethylene oxide, styrene, vinyl chloride, epichlorohydrin, propylene oxide, 4,4'-methylenebis-2-chloroaniline, benzidine, benzidine dyes (Direct Blue 6, Direct Black 38 and Direct Brown 95), acrylonitrile and benzyl chloride. While some of these chemicals (styrene and benzyl chloride, possibly Direct Blue 6) give rise to unique DNA adducts, others do not. Potentially confounding factors include mixed exposures in the work place, as well the formation of common DNA adducts. Additional research needs are identified.

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Published In

Mutation research

DOI

EISSN

1873-135X

ISSN

0027-5107

Publication Date

July 1992

Volume

277

Issue

1

Start / End Page

35 / 90

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutagens
  • Humans
  • Feasibility Studies
  • Epidemiologic Methods
  • DNA Damage
  • Animals
  • 3105 Genetics
 

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Uziel, M., Munro, N. B., Katz, D. S., Vo-Dinh, T., Zeighami, E. A., Waters, M. D., & Griffith, J. D. (1992). DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation Research, 277(1), 35–90. https://doi.org/10.1016/0165-1110(92)90025-5
Uziel, M., N. B. Munro, D. S. Katz, T. Vo-Dinh, E. A. Zeighami, M. D. Waters, and J. D. Griffith. “DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies.Mutation Research 277, no. 1 (July 1992): 35–90. https://doi.org/10.1016/0165-1110(92)90025-5.
Uziel M, Munro NB, Katz DS, Vo-Dinh T, Zeighami EA, Waters MD, et al. DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation research. 1992 Jul;277(1):35–90.
Uziel, M., et al. “DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies.Mutation Research, vol. 277, no. 1, July 1992, pp. 35–90. Epmc, doi:10.1016/0165-1110(92)90025-5.
Uziel M, Munro NB, Katz DS, Vo-Dinh T, Zeighami EA, Waters MD, Griffith JD. DNA adduct formation by 12 chemicals with populations potentially suitable for molecular epidemiological studies. Mutation research. 1992 Jul;277(1):35–90.

Published In

Mutation research

DOI

EISSN

1873-135X

ISSN

0027-5107

Publication Date

July 1992

Volume

277

Issue

1

Start / End Page

35 / 90

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutagens
  • Humans
  • Feasibility Studies
  • Epidemiologic Methods
  • DNA Damage
  • Animals
  • 3105 Genetics