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Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats

Publication ,  Journal Article
Frazier, DL; Barnhill, MA; Vodinh, T; Legendre, AM; Overholt, BF
Published in: Journal of Veterinary Pharmacology and Therapeutics
1992

Photodynamic therapy is a promising new treatment for local eradication of cancer. Little work has been done to define the pharmacokinetics of photodynamic drugs or the variability in drug disposition that may occur between different species and pathophysiological states of tissues. Pharmacokinetic studies of tin-etiopurpurin (SnET2), a lipophilic photosensitizer, were conducted on six Beagle dogs and six Sprague-Dawley rats. Blood was collected up to 24 h following drug administration for measurement of tin-etiopurpurin concentration. Dogs and rats were euthanatized 24 h post-administration and tissues were collected for drug analyses. The plasma drug concentrations were best described by a 2-compartment model (Ct = Ae(-αt) + Be(-βt)). Median distribution and elimination half-lives were 0.24 and 0.34 h and 10.21 and 5.25 h for dogs and rats, respectively. The apparent volumes of distribution were 4.26 ± 1.75 L/kg for dogs and 1.84 ± 0.36 L/kg for rats. Systemic clearance was 7.56 ± 2.45 ml/kg/min and 6.63 ± 0.91 ml/kg/min for dogs and rats, respectively. Drug was detected in all tissues analyzed 24 h after drug administration. Drug was detected only sporadically in skin and muscle and was generally below the limit of detection of the assay. Where comparison could be made, concentrations of SnET2 were significantly greater in all tissues except jejunum of rats compared to dogs 24 h after drug administration.

Duke Scholars

Published In

Journal of Veterinary Pharmacology and Therapeutics

Publication Date

1992

Volume

15

Issue

3

Start / End Page

275 / 281

Related Subject Headings

  • Veterinary Sciences
  • 0707 Veterinary Sciences
 

Citation

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Frazier, D. L., Barnhill, M. A., Vodinh, T., Legendre, A. M., & Overholt, B. F. (1992). Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats. Journal of Veterinary Pharmacology and Therapeutics, 15(3), 275–281.
Frazier, D. L., M. A. Barnhill, T. Vodinh, A. M. Legendre, and B. F. Overholt. “Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats.” Journal of Veterinary Pharmacology and Therapeutics 15, no. 3 (1992): 275–81.
Frazier DL, Barnhill MA, Vodinh T, Legendre AM, Overholt BF. Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats. Journal of Veterinary Pharmacology and Therapeutics. 1992;15(3):275–81.
Frazier, D. L., et al. “Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats.” Journal of Veterinary Pharmacology and Therapeutics, vol. 15, no. 3, 1992, pp. 275–81.
Frazier DL, Barnhill MA, Vodinh T, Legendre AM, Overholt BF. Comparative pharmacokinetics of the photosensitizer tin-etiopurpurin in dogs and rats. Journal of Veterinary Pharmacology and Therapeutics. 1992;15(3):275–281.

Published In

Journal of Veterinary Pharmacology and Therapeutics

Publication Date

1992

Volume

15

Issue

3

Start / End Page

275 / 281

Related Subject Headings

  • Veterinary Sciences
  • 0707 Veterinary Sciences