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Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.

Publication ,  Journal Article
Kaslow, RA; Rivers, C; Tang, J; Bender, TJ; Goepfert, PA; El Habib, R; Weinhold, K; Mulligan, MJ; NIAID AIDS vaccine evaluation group,
Published in: J Virol
September 2001

Carriers of certain human leukocyte antigen class I alleles show favorable prognosis of human immunodeficiency virus type 1 (HIV-1) infection, presumably due to effective CD8(+) cytotoxic T-lymphocyte responses, but close relationships between class I variants mediating such responses to natural and to vaccine HIV-1 antigen have not been established. During 6 to 30 months of administration and follow-up in trials of ALVAC-HIV recombinant canarypox vaccines, cells from 42% of 291 HIV-1-negative vaccinated subjects typed at class I loci responded to an HIV-1 protein in a lytic bulk CD8(+) cytotoxic T-lymphocyte assay. By 2 weeks after the second dose, higher proportions of vaccinees carrying one of two alleles consistently associated with slower progression of natural HIV-1 infection reacted at least once: B*27 carriers reacted to Gag (64%; odds ratio [OR] = 10.3, P = 0.001) and Env (36%; OR = 4.6, P = 0.04), and B*57 carriers reacted to Env (44%; OR = 6.6, P < 0.05). By 2 weeks after the third or fourth dose, B*27 carriers had responded (two or more reactions) to Gag (33%; OR = 4.4, P < 0.05) and B*57 carriers had responded to both Gag (39%; OR = 5.3, P = 0.013) and Env (39%; OR = 9.5, P = 0.002). Homozygosity at class I loci, although conferring an unfavorable prognosis following natural infection, showed no such disadvantage for vaccine response. Individual class I alleles have not previously demonstrated such clear and consistent relationship with both the clinical course of an infection and cellular immunity to a vaccine against the infectious agent. This proof of principle that class I an alleles modulate both processes has implications for development of HIV-1 and presumably other vaccines.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

September 2001

Volume

75

Issue

18

Start / End Page

8681 / 8689

Location

United States

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • T-Lymphocytes, Cytotoxic
  • Sexual Behavior
  • Risk-Taking
  • Risk Factors
  • Prognosis
  • Polymorphism, Genetic
  • Middle Aged
  • Humans
 

Citation

APA
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Kaslow, R. A., Rivers, C., Tang, J., Bender, T. J., Goepfert, P. A., El Habib, R., … NIAID AIDS vaccine evaluation group, . (2001). Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines. J Virol, 75(18), 8681–8689. https://doi.org/10.1128/jvi.75.18.8681-8689.2001
Kaslow, R. A., C. Rivers, J. Tang, T. J. Bender, P. A. Goepfert, R. El Habib, K. Weinhold, M. J. Mulligan, and M. J. NIAID AIDS vaccine evaluation group. “Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.J Virol 75, no. 18 (September 2001): 8681–89. https://doi.org/10.1128/jvi.75.18.8681-8689.2001.
Kaslow RA, Rivers C, Tang J, Bender TJ, Goepfert PA, El Habib R, Weinhold K, Mulligan MJ, NIAID AIDS vaccine evaluation group. Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines. J Virol. 2001 Sep;75(18):8681–8689.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

September 2001

Volume

75

Issue

18

Start / End Page

8681 / 8689

Location

United States

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • T-Lymphocytes, Cytotoxic
  • Sexual Behavior
  • Risk-Taking
  • Risk Factors
  • Prognosis
  • Polymorphism, Genetic
  • Middle Aged
  • Humans