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Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women.

Publication ,  Journal Article
Wright, PF; Lambert, JS; Gorse, GJ; Hsieh, RH; McElrath, MJ; Weinhold, K; Wara, DW; Anderson, EL; Keefer, MC; Jackson, S; Wagner, LJ; Fast, PE ...
Published in: J Infect Dis
October 1999

Twenty-six human immunodeficiency virus (HIV)-infected pregnant women participated in a placebo-controlled study of immunogenicity and safety of multiple doses of MN rgp120 vaccine over the last half of pregnancy. The women had CD4 lymphocyte counts>400/mm3, no AIDS-defining illness and normal pregnancies. Vaccination was well tolerated, with no significant local or systemic reactions in the women and no adverse outcomes in the infants attributable to the vaccine. Vaccination did not alter plasma RNA reverse transcriptase-polymerase chain reaction copy number; moreover, immunization was not associated with changes in CD4 counts or HIV binding and neutralization antibody titers. Infants were followed up until 18 months of age. Five of 26 infants (19%) were HIV infected, with infection occurring in children of both vaccinated and placebo women. Analysis of factors that influence transmission did not disclose associations with immunization status, viral load, CD4 count, or maternal viral neutralization titers.

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Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 1999

Volume

180

Issue

4

Start / End Page

1080 / 1088

Location

United States

Related Subject Headings

  • Vaccines, Synthetic
  • Time Factors
  • Safety
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Placebos
  • Microbiology
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Humans
 

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Wright, P. F., Lambert, J. S., Gorse, G. J., Hsieh, R. H., McElrath, M. J., Weinhold, K., … McNamara, J. (1999). Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women. J Infect Dis, 180(4), 1080–1088. https://doi.org/10.1086/314985
Wright, P. F., J. S. Lambert, G. J. Gorse, R. H. Hsieh, M. J. McElrath, K. Weinhold, D. W. Wara, et al. “Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women.J Infect Dis 180, no. 4 (October 1999): 1080–88. https://doi.org/10.1086/314985.
Wright PF, Lambert JS, Gorse GJ, Hsieh RH, McElrath MJ, Weinhold K, et al. Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women. J Infect Dis. 1999 Oct;180(4):1080–8.
Wright, P. F., et al. “Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women.J Infect Dis, vol. 180, no. 4, Oct. 1999, pp. 1080–88. Pubmed, doi:10.1086/314985.
Wright PF, Lambert JS, Gorse GJ, Hsieh RH, McElrath MJ, Weinhold K, Wara DW, Anderson EL, Keefer MC, Jackson S, Wagner LJ, Francis DP, Fast PE, McNamara J. Immunization with envelope MN rgp120 vaccine in human immunodeficiency virus-infected pregnant women. J Infect Dis. 1999 Oct;180(4):1080–1088.

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

October 1999

Volume

180

Issue

4

Start / End Page

1080 / 1088

Location

United States

Related Subject Headings

  • Vaccines, Synthetic
  • Time Factors
  • Safety
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Placebos
  • Microbiology
  • Infectious Disease Transmission, Vertical
  • Infant, Newborn
  • Humans