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Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria.

Publication ,  Journal Article
Schaber, J; Rispe, C; Wernegreen, J; Buness, A; Delmotte, F; Silva, FJ; Moya, A
Published in: Gene
June 2005

Most endosymbiotic bacteria have extremely reduced genomes, accelerated evolutionary rates, and strong AT base compositional bias thought to reflect reduced efficacy of selection and increased mutational pressure. Here, we present a comparative study of evolutionary forces shaping five fully sequenced bacterial endosymbionts of insects. The results of this study were three-fold: (i) Stronger conservation of high expression genes at not just nonsynonymous, but also synonymous, sites. (ii) Variation in amino acid usage strongly correlates with GC content and expression level of genes. This pattern is largely explained by greater conservation of high expression genes, leading to their higher GC content. However, we also found indication of selection favoring GC-rich amino acids that contrasts with former studies. (iii) Although the specific nutritional requirements of the insect host are known to affect gene content of endosymbionts, we found no detectable influence on substitution rates, amino acid usage, or codon usage of bacterial genes involved in host nutrition.

Duke Scholars

Published In

Gene

DOI

EISSN

1879-0038

ISSN

0378-1119

Publication Date

June 2005

Volume

352

Start / End Page

109 / 117

Related Subject Headings

  • Wigglesworthia
  • Symbiosis
  • Species Specificity
  • Mutation
  • Insecta
  • Gene Expression Regulation, Bacterial
  • GC Rich Sequence
  • Evolution, Molecular
  • Developmental Biology
  • Databases, Nucleic Acid
 

Citation

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Schaber, J., Rispe, C., Wernegreen, J., Buness, A., Delmotte, F., Silva, F. J., & Moya, A. (2005). Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria. Gene, 352, 109–117. https://doi.org/10.1016/j.gene.2005.04.003
Schaber, Jörg, Claude Rispe, Jennifer Wernegreen, Andreas Buness, François Delmotte, Francisco J. Silva, and Andrés Moya. “Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria.Gene 352 (June 2005): 109–17. https://doi.org/10.1016/j.gene.2005.04.003.
Schaber J, Rispe C, Wernegreen J, Buness A, Delmotte F, Silva FJ, et al. Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria. Gene. 2005 Jun;352:109–17.
Schaber, Jörg, et al. “Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria.Gene, vol. 352, June 2005, pp. 109–17. Epmc, doi:10.1016/j.gene.2005.04.003.
Schaber J, Rispe C, Wernegreen J, Buness A, Delmotte F, Silva FJ, Moya A. Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria. Gene. 2005 Jun;352:109–117.
Journal cover image

Published In

Gene

DOI

EISSN

1879-0038

ISSN

0378-1119

Publication Date

June 2005

Volume

352

Start / End Page

109 / 117

Related Subject Headings

  • Wigglesworthia
  • Symbiosis
  • Species Specificity
  • Mutation
  • Insecta
  • Gene Expression Regulation, Bacterial
  • GC Rich Sequence
  • Evolution, Molecular
  • Developmental Biology
  • Databases, Nucleic Acid