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Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition.

Publication ,  Journal Article
Wernegreen, JJ; Richardson, AO; Moran, NA
Published in: Molecular phylogenetics and evolution
June 2001

The overproduction of essential amino acids by Buchnera aphidicola, the primary bacterial mutualist of aphids, is considered an adaptation for increased production of nutrients that are lacking in aphids' diet of plant sap. Given their shared role in host nutrition, amino acid biosynthetic genes of Buchnera are expected to experience parallel changes in selection that depend on host diet quality, growth rate, and population structure. This study evaluates the hypothesis of parallel selection across biosynthetic pathways by testing for correlated changes in evolutionary rates at biosynthetic genes of Buchnera. Previous studies show fast evolutionary rates at tryptophan biosynthetic genes among Buchnera associated with the aphid genus Uroleucon and suggest reduced purifying selection on symbiont nutritional functions in this aphid group. Here, we test for parallel rate acceleration at other amino acid biosynthetic genes of Buchnera-Uroleucon, including those for leucine (leuABC) and isoleucine/valine biosynthesis (ilvC). Ratios of nonsynonymous to synonymous substitutions (d(N)/d(S)) were estimated using codon-based maximum-likelihood methods that account for the extreme AT compositional bias of Buchnera sequences. A significant elevation in d(N)/d(S) at biosynthetic loci but not at two housekeeping genes sampled (dnaN and tuf) suggests reduced host-level selection on biosynthetic capabilities of Buchnera-Uroleucon. In addition, the discovery of trpEG pseudogenes in Buchnera-U. obscurum further supports reduced selection on amino acid biosynthesis.

Duke Scholars

Published In

Molecular phylogenetics and evolution

DOI

EISSN

1095-9513

ISSN

1055-7903

Publication Date

June 2001

Volume

19

Issue

3

Start / End Page

479 / 485

Related Subject Headings

  • Symbiosis
  • Sequence Analysis, DNA
  • Pseudogenes
  • Phylogeny
  • Nitrogenous Group Transferases
  • Molecular Sequence Data
  • Ketol-Acid Reductoisomerase
  • Evolutionary Biology
  • Evolution, Molecular
  • DNA, Bacterial
 

Citation

APA
Chicago
ICMJE
MLA
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Wernegreen, J. J., Richardson, A. O., & Moran, N. A. (2001). Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition. Molecular Phylogenetics and Evolution, 19(3), 479–485. https://doi.org/10.1006/mpev.2001.0929
Wernegreen, J. J., A. O. Richardson, and N. A. Moran. “Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition.Molecular Phylogenetics and Evolution 19, no. 3 (June 2001): 479–85. https://doi.org/10.1006/mpev.2001.0929.
Wernegreen JJ, Richardson AO, Moran NA. Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition. Molecular phylogenetics and evolution. 2001 Jun;19(3):479–85.
Wernegreen, J. J., et al. “Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition.Molecular Phylogenetics and Evolution, vol. 19, no. 3, June 2001, pp. 479–85. Epmc, doi:10.1006/mpev.2001.0929.
Wernegreen JJ, Richardson AO, Moran NA. Parallel acceleration of evolutionary rates in symbiont genes underlying host nutrition. Molecular phylogenetics and evolution. 2001 Jun;19(3):479–485.
Journal cover image

Published In

Molecular phylogenetics and evolution

DOI

EISSN

1095-9513

ISSN

1055-7903

Publication Date

June 2001

Volume

19

Issue

3

Start / End Page

479 / 485

Related Subject Headings

  • Symbiosis
  • Sequence Analysis, DNA
  • Pseudogenes
  • Phylogeny
  • Nitrogenous Group Transferases
  • Molecular Sequence Data
  • Ketol-Acid Reductoisomerase
  • Evolutionary Biology
  • Evolution, Molecular
  • DNA, Bacterial