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Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy.

Publication ,  Journal Article
Proulx, GM; Willett, CG; Daley, W; Shellito, PC
Published in: J Surg Oncol
September 1997

BACKGROUND AND OBJECTIVES: Primary adenocarcinoma of the appendix is rare, which makes an understanding of its natural history difficult. To date, it is treated predominantly with surgery alone. This review aims to elucidate the patterns of failure and treatment outcomes when adjuvant treatment is given after primary surgical resection. METHODS: Twenty-three patients were treated with either surgery alone, or with surgery and adjuvant radiation +/- chemotherapy. A review of the clinical course of these patients was undertaken with an analysis of the local control, distant failure, disease-free survival, and overall survival. RESULTS: Most patients presented with local invasion or metastatic disease often involving the peritoneum. Overall survival was 32%, similar to the results of other studies. Analysis of patients with locally advanced disease showed improvement in overall survival and local control with postoperative radiation therapy compared to surgery alone. CONCLUSIONS: Adenocarcinoma of the appendix is a rare disease that presents most often in an advanced stage. It has been shown by others that a right hemicolectomy provides the best outcome with respect to surgical procedure. Postoperative irradiation appears to provide a benefit for both local control and overall survival.

Duke Scholars

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

September 1997

Volume

66

Issue

1

Start / End Page

51 / 53

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Survival Rate
  • Radiotherapy, Adjuvant
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorouracil
 

Citation

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ICMJE
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Proulx, G. M., Willett, C. G., Daley, W., & Shellito, P. C. (1997). Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy. J Surg Oncol, 66(1), 51–53. https://doi.org/10.1002/(sici)1096-9098(199709)66:1<51::aid-jso10>3.0.co;2-r
Proulx, G. M., C. G. Willett, W. Daley, and P. C. Shellito. “Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy.J Surg Oncol 66, no. 1 (September 1997): 51–53. https://doi.org/10.1002/(sici)1096-9098(199709)66:1<51::aid-jso10>3.0.co;2-r.
Proulx GM, Willett CG, Daley W, Shellito PC. Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy. J Surg Oncol. 1997 Sep;66(1):51–3.
Proulx, G. M., et al. “Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy.J Surg Oncol, vol. 66, no. 1, Sept. 1997, pp. 51–53. Pubmed, doi:10.1002/(sici)1096-9098(199709)66:1<51::aid-jso10>3.0.co;2-r.
Proulx GM, Willett CG, Daley W, Shellito PC. Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy. J Surg Oncol. 1997 Sep;66(1):51–53.
Journal cover image

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

September 1997

Volume

66

Issue

1

Start / End Page

51 / 53

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Survival Rate
  • Radiotherapy, Adjuvant
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Fluorouracil