beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.
Publication
, Journal Article
Sundar, KS; Kamaraju, LS; Dingfelder, J; McMahon, J; Gollapudi, S; Wilson, WH; Kong, LY; Hong, JS; Weiss, JM; Lee, JE
Published in: J Neuroimmunol
August 1995
The effect of an endogenous opiate, beta-endorphin, on the replication of HIV was investigated in brain perivascular microglia. Beta-endorphin enhanced the synthesis of p-24 antigen and transactivation of HIV promoter. Dialysed culture supernatants of endorphin-treated microglia re-activated latent HIV infection. These culture supernatants showed elevated levels of interleukin-1 beta, IL-6 and tumor necrosis factor alpha. Sub-optimal concentration of beta-endorphin potentiated GP-120-induced synthesis of these cytokines. Nalaxone reversed beta-endorphin-induced, but not GP-120-induced, cytokine production and enhanced HIV replication. These results suggest that endogenous opiates may contribute to the progression of AIDS dementia complex.
Duke Scholars
Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
August 1995
Volume
61
Issue
1
Start / End Page
97 / 104
Location
Netherlands
Related Subject Headings
- beta-Endorphin
- Virus Replication
- Virus Latency
- Transcriptional Activation
- Neurology & Neurosurgery
- Narcotic Antagonists
- Naloxone
- Microglia
- In Vitro Techniques
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Sundar, K. S., Kamaraju, L. S., Dingfelder, J., McMahon, J., Gollapudi, S., Wilson, W. H., … Lee, J. E. (1995). beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia. J Neuroimmunol, 61(1), 97–104. https://doi.org/10.1016/0165-5728(95)00089-k
Sundar, K. S., L. S. Kamaraju, J. Dingfelder, J. McMahon, S. Gollapudi, W. H. Wilson, L. Y. Kong, J. S. Hong, J. M. Weiss, and J. E. Lee. “beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.” J Neuroimmunol 61, no. 1 (August 1995): 97–104. https://doi.org/10.1016/0165-5728(95)00089-k.
Sundar KS, Kamaraju LS, Dingfelder J, McMahon J, Gollapudi S, Wilson WH, et al. beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia. J Neuroimmunol. 1995 Aug;61(1):97–104.
Sundar, K. S., et al. “beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.” J Neuroimmunol, vol. 61, no. 1, Aug. 1995, pp. 97–104. Pubmed, doi:10.1016/0165-5728(95)00089-k.
Sundar KS, Kamaraju LS, Dingfelder J, McMahon J, Gollapudi S, Wilson WH, Kong LY, Hong JS, Weiss JM, Lee JE. beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia. J Neuroimmunol. 1995 Aug;61(1):97–104.
Published In
J Neuroimmunol
DOI
ISSN
0165-5728
Publication Date
August 1995
Volume
61
Issue
1
Start / End Page
97 / 104
Location
Netherlands
Related Subject Headings
- beta-Endorphin
- Virus Replication
- Virus Latency
- Transcriptional Activation
- Neurology & Neurosurgery
- Narcotic Antagonists
- Naloxone
- Microglia
- In Vitro Techniques
- Humans