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Treatment of social phobia with clonazepam and placebo.

Publication ,  Journal Article
Davidson, JR; Potts, N; Richichi, E; Krishnan, R; Ford, SM; Smith, R; Wilson, WH
Published in: J Clin Psychopharmacol
December 1993

Clonazepam and placebo were administered in a double-blind pilot study to 75 outpatients with social phobia. The mean maximum dose of clonazepam was 2.4 mg/day at endpoint (range, 0.5 to 3 mg). Treatment was continued for up to 10 weeks. The results of an intent-to-treat analysis indicated superior effects of clonazepam on most measures. Response rates for clonazepam and placebo were 78.3 and 20.0%. Drug effects were apparent on performance and generalized social anxiety, on fear and phobic avoidance, on interpersonal sensitivity, on fears of negative evaluation, and on disability measures. Significant differences were evident by week 1, 2, or 6, depending upon the rating scale used. Clonazepam was well tolerated in general, although unsteadiness and dizziness were more severe and persistent than was the case for placebo subjects.

Duke Scholars

Published In

J Clin Psychopharmacol

ISSN

0271-0749

Publication Date

December 1993

Volume

13

Issue

6

Start / End Page

423 / 428

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Phobic Disorders
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Clonazepam
  • Anxiety
 

Citation

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Davidson, J. R., Potts, N., Richichi, E., Krishnan, R., Ford, S. M., Smith, R., & Wilson, W. H. (1993). Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol, 13(6), 423–428.
Davidson, J. R., N. Potts, E. Richichi, R. Krishnan, S. M. Ford, R. Smith, and W. H. Wilson. “Treatment of social phobia with clonazepam and placebo.J Clin Psychopharmacol 13, no. 6 (December 1993): 423–28.
Davidson JR, Potts N, Richichi E, Krishnan R, Ford SM, Smith R, et al. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol. 1993 Dec;13(6):423–8.
Davidson, J. R., et al. “Treatment of social phobia with clonazepam and placebo.J Clin Psychopharmacol, vol. 13, no. 6, Dec. 1993, pp. 423–28.
Davidson JR, Potts N, Richichi E, Krishnan R, Ford SM, Smith R, Wilson WH. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol. 1993 Dec;13(6):423–428.

Published In

J Clin Psychopharmacol

ISSN

0271-0749

Publication Date

December 1993

Volume

13

Issue

6

Start / End Page

423 / 428

Location

United States

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Pilot Projects
  • Phobic Disorders
  • Male
  • Humans
  • Female
  • Double-Blind Method
  • Clonazepam
  • Anxiety