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Cerebral blood flow changes induced by CO2 in anxiety.

Publication ,  Journal Article
Mathew, RJ; Wilson, WH
Published in: Psychiatry Res
March 1988

Cerebral blood flow (CBF) was measured twice with the 133Xenon inhalation technique, under resting conditions and during 5% CO2 inhalation, in 13 patients with generalized anxiety disorder and a group of normal volunteers of comparable age and sex distribution. CO2 inhalation was associated with similar increases in end-tidal CO2 (PECO2) and CBF. Neither group showed statistically significant increases in state anxiety. However, when subjects (both patients and controls) who became anxious during CO2 inhalation were compared with those who did not, on associated CBF changes, significant differences emerged. The former showed less marked CBF increase as compared to the latter in the absence of any significant differences between the two groups on PECO2 during the second measurement. Changes in state anxiety and CBF showed a statistically significant inverse correlation for the entire group.

Duke Scholars

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

March 1988

Volume

23

Issue

3

Start / End Page

285 / 294

Location

Ireland

Related Subject Headings

  • Xenon Radioisotopes
  • Regional Blood Flow
  • Psychiatry
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Dominance, Cerebral
  • Cerebrovascular Circulation
  • Carbon Dioxide
 

Citation

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Chicago
ICMJE
MLA
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Mathew, R. J., & Wilson, W. H. (1988). Cerebral blood flow changes induced by CO2 in anxiety. Psychiatry Res, 23(3), 285–294. https://doi.org/10.1016/0165-1781(88)90019-4
Mathew, R. J., and W. H. Wilson. “Cerebral blood flow changes induced by CO2 in anxiety.Psychiatry Res 23, no. 3 (March 1988): 285–94. https://doi.org/10.1016/0165-1781(88)90019-4.
Mathew RJ, Wilson WH. Cerebral blood flow changes induced by CO2 in anxiety. Psychiatry Res. 1988 Mar;23(3):285–94.
Mathew, R. J., and W. H. Wilson. “Cerebral blood flow changes induced by CO2 in anxiety.Psychiatry Res, vol. 23, no. 3, Mar. 1988, pp. 285–94. Pubmed, doi:10.1016/0165-1781(88)90019-4.
Mathew RJ, Wilson WH. Cerebral blood flow changes induced by CO2 in anxiety. Psychiatry Res. 1988 Mar;23(3):285–294.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

March 1988

Volume

23

Issue

3

Start / End Page

285 / 294

Location

Ireland

Related Subject Headings

  • Xenon Radioisotopes
  • Regional Blood Flow
  • Psychiatry
  • Male
  • Humans
  • Female
  • Electroencephalography
  • Dominance, Cerebral
  • Cerebrovascular Circulation
  • Carbon Dioxide