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Pharmacologically defined components of the normal porcine multifocal ERG.

Publication ,  Journal Article
Ng, Y-F; Chan, HHL; Chu, PHW; Siu, AW; To, C-H; Beale, BA; Gilger, BC; Wong, F
Published in: Doc Ophthalmol
May 2008

Multifocal electroretinograms (mfERG) from isoflurane anesthetized pigs were recorded and sequential application of TTX, NMDA, APB and PDA were used to identify contributions to the mfERG from inner retinal neurons, ON-pathway, OFF-pathway and photoreceptors. The cellular origins of the first-order kernel (K1) and the first slice of the second-order kernel (K2.1) porcine mfERG are contributed from both inner and outer retina. For the K1 waveform, the n1 involved responses of cone photoreceptors and OFF-bipolar cells. The leading edge of p1 is dominated by ON-bipolar cell depolarization. The rear edge of p1, n2 and p2 are dominated by ON-bipolar activities and shaped by the activities of OFF-bipolar cells and retinal cells with NMDAr and voltage-gated sodium channels other than ganglion cells. The p3 is mainly inner retinal activities. For the K2.1 waveform, the p1 and n1 are the summation of activities of ON-, OFF-bipolar cells and retinal cells rich in NMDAr and voltage-gated sodium channels other than ganglion cells. The p2 seems to be related to the ganglion cells. Better understanding of the cellular origins of the normal porcine mfERG will be useful for comparing and defining the functional changes that may occur in diseased retinas.

Duke Scholars

Published In

Doc Ophthalmol

DOI

ISSN

0012-4486

Publication Date

May 2008

Volume

116

Issue

3

Start / End Page

165 / 176

Location

Netherlands

Related Subject Headings

  • Vitreous Body
  • Tetrodotoxin
  • Swine
  • Sodium Channels
  • Sodium Channel Blockers
  • Retinal Bipolar Cells
  • Retina
  • Receptors, N-Methyl-D-Aspartate
  • Pipecolic Acids
  • Ophthalmology & Optometry
 

Citation

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ICMJE
MLA
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Ng, Y.-F., Chan, H. H. L., Chu, P. H. W., Siu, A. W., To, C.-H., Beale, B. A., … Wong, F. (2008). Pharmacologically defined components of the normal porcine multifocal ERG. Doc Ophthalmol, 116(3), 165–176. https://doi.org/10.1007/s10633-007-9076-7
Ng, Yiu-Fai, Henry H. L. Chan, Patrick H. W. Chu, Andrew W. Siu, Chi-Ho To, Brady A. Beale, Brian C. Gilger, and Fulton Wong. “Pharmacologically defined components of the normal porcine multifocal ERG.Doc Ophthalmol 116, no. 3 (May 2008): 165–76. https://doi.org/10.1007/s10633-007-9076-7.
Ng Y-F, Chan HHL, Chu PHW, Siu AW, To C-H, Beale BA, et al. Pharmacologically defined components of the normal porcine multifocal ERG. Doc Ophthalmol. 2008 May;116(3):165–76.
Ng, Yiu-Fai, et al. “Pharmacologically defined components of the normal porcine multifocal ERG.Doc Ophthalmol, vol. 116, no. 3, May 2008, pp. 165–76. Pubmed, doi:10.1007/s10633-007-9076-7.
Ng Y-F, Chan HHL, Chu PHW, Siu AW, To C-H, Beale BA, Gilger BC, Wong F. Pharmacologically defined components of the normal porcine multifocal ERG. Doc Ophthalmol. 2008 May;116(3):165–176.
Journal cover image

Published In

Doc Ophthalmol

DOI

ISSN

0012-4486

Publication Date

May 2008

Volume

116

Issue

3

Start / End Page

165 / 176

Location

Netherlands

Related Subject Headings

  • Vitreous Body
  • Tetrodotoxin
  • Swine
  • Sodium Channels
  • Sodium Channel Blockers
  • Retinal Bipolar Cells
  • Retina
  • Receptors, N-Methyl-D-Aspartate
  • Pipecolic Acids
  • Ophthalmology & Optometry