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Role of hypoxia in inflammatory upper airway disease.

Publication ,  Journal Article
Steinke, JW; Woodard, CR; Borish, L
Published in: Curr Opin Allergy Clin Immunol
February 2008

PURPOSE OF REVIEW: Hypoxia is a potent stimulus for inflammation and remodeling. Hypoxia develops in chronic sinusitis as shown via tissue oxygen concentrations and colonization with obligate anaerobes. This hypoxia reflects occlusion of the sinus ostia and thereby failure of transepithelial oxygenation, nonvascularized exudates, and the tendency of inflammatory hyperplasia to exceed neovascularization. RECENT FINDINGS: Hypoxia-induced transcription factors are responsible for transcription of numerous inflammatory cytokines and growth factors, including vascular endothelial growth factor, CXCL8, CCL11, transforming growth factor-beta, inducible nitric oxide synthase, as well as matrix remodeling proteins such as procollagen and matrix metalloproteinases. SUMMARY: Many diseases, such as asthma, share the tendency to afflict respiratory epithelium of the lower (bronchi) and upper (sinus) airway. Although the histopathology and inflammation of asthma and its associated sinusitis share many features, aggressive fibrosis, polyp formation and intense hyperplasia are not features of asthma, a disease seldom associated with significant chronic hypoxia. In contrast, fibrosis is a cardinal feature of hypoxic diseases of the lungs such as interstitial lung diseases and primary pulmonary hypertension. Arguably, chronic sinusitis can be viewed as reflecting both 'asthma' and 'primary pulmonary hypertension' of the upper airway.

Duke Scholars

Published In

Curr Opin Allergy Clin Immunol

DOI

ISSN

1528-4050

Publication Date

February 2008

Volume

8

Issue

1

Start / End Page

16 / 20

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Sinusitis
  • Respiratory Mucosa
  • Respiration Disorders
  • Inflammation
  • Hypoxia
  • Humans
  • Fibrosis
  • Extracellular Matrix Proteins
  • Chronic Disease
 

Citation

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ICMJE
MLA
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Steinke, J. W., Woodard, C. R., & Borish, L. (2008). Role of hypoxia in inflammatory upper airway disease. Curr Opin Allergy Clin Immunol, 8(1), 16–20. https://doi.org/10.1097/ACI.0b013e3282f3f488
Steinke, John W., Charles R. Woodard, and Larry Borish. “Role of hypoxia in inflammatory upper airway disease.Curr Opin Allergy Clin Immunol 8, no. 1 (February 2008): 16–20. https://doi.org/10.1097/ACI.0b013e3282f3f488.
Steinke JW, Woodard CR, Borish L. Role of hypoxia in inflammatory upper airway disease. Curr Opin Allergy Clin Immunol. 2008 Feb;8(1):16–20.
Steinke, John W., et al. “Role of hypoxia in inflammatory upper airway disease.Curr Opin Allergy Clin Immunol, vol. 8, no. 1, Feb. 2008, pp. 16–20. Pubmed, doi:10.1097/ACI.0b013e3282f3f488.
Steinke JW, Woodard CR, Borish L. Role of hypoxia in inflammatory upper airway disease. Curr Opin Allergy Clin Immunol. 2008 Feb;8(1):16–20.

Published In

Curr Opin Allergy Clin Immunol

DOI

ISSN

1528-4050

Publication Date

February 2008

Volume

8

Issue

1

Start / End Page

16 / 20

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Sinusitis
  • Respiratory Mucosa
  • Respiration Disorders
  • Inflammation
  • Hypoxia
  • Humans
  • Fibrosis
  • Extracellular Matrix Proteins
  • Chronic Disease