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Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells.

Publication ,  Journal Article
Yen, PM; Tashjian, AH
Published in: Endocrinology
July 1981

Treatment of GH3 cells for 24-72 h with sodium valerate (1 mM) increased 2- to 4-fold the production of both PRL and GH. There was a concomitant change in the morphology of the cells that resembled that produced by TRH and epidermal growth factor. The increases in hormone production and changes in morphology were reversible. The sodium salts of butyric, hexanoic, caprylic, nonanoic, and dodecanoic acids also increased hormone production and altered cell morphology, whereas the salts of formic, acetic, and isobutyric acids did not. Acute (1-h) treatment with the fatty acids, unlike the effects of TRH and epidermal growth factor, did not increase the release of PRL from the cells.

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Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 1981

Volume

109

Issue

1

Start / End Page

17 / 22

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Rats
  • Prolactin
  • Pituitary Neoplasms
  • Neoplasms, Experimental
  • Kinetics
  • Growth Hormone
  • Fatty Acids
  • Endocrinology & Metabolism
  • Cell Line
 

Citation

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Yen, P. M., & Tashjian, A. H. (1981). Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells. Endocrinology, 109(1), 17–22. https://doi.org/10.1210/endo-109-1-17
Yen, P. M., and A. H. Tashjian. “Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells.Endocrinology 109, no. 1 (July 1981): 17–22. https://doi.org/10.1210/endo-109-1-17.
Yen, P. M., and A. H. Tashjian. “Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH3 strain of rat pituitary cells.Endocrinology, vol. 109, no. 1, July 1981, pp. 17–22. Pubmed, doi:10.1210/endo-109-1-17.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

July 1981

Volume

109

Issue

1

Start / End Page

17 / 22

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Rats
  • Prolactin
  • Pituitary Neoplasms
  • Neoplasms, Experimental
  • Kinetics
  • Growth Hormone
  • Fatty Acids
  • Endocrinology & Metabolism
  • Cell Line