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Influences of inbreeding and genetics on telomere length in mice.

Publication ,  Journal Article
Manning, EL; Crossland, J; Dewey, MJ; Van Zant, G
Published in: Mamm Genome
May 2002

We measured telomere lengths of blood leukocytes in several inbred and outbred mammalian species, using a telomere-specific fluorescent probe and flow cytometry. Humans, non-human primates, and three outbred populations of Peromyscus mice ( Peromyscus leucopus, Peromyscus maniculatus, and Peromyscus polionotus) have short telomeres. Two common strains of laboratory mice, C57BL/6J and DBA/2J, have telomeres several times longer than most other mammals surveyed. Moreover, the two inbred laboratory mouse strains display significantly different telomere lengths, suggesting the existence of strain-specific genetic determinants. To further examine the effects of inbreeding, we studied three Peromyscus leucopus inbred lines (GS109, GS16A1, and GS16B), all derived from the outbred P. leucopus stock. Telomeres of all three inbred lines are significantly lengthened relative to outbred P. leucopus, and the three lines display strain-specific significantly different telomere lengths, much like the C57BL/6J and DBA/2J strains of M. musculus. To further characterize the genetic inheritance of telomere length, we carried out several crosses to obtain hybrid F(1) mice between parental strains displaying the phenotype of long and short telomeres. In all F(1) mice assayed, peripheral blood leukocyte telomere length was intermediate to that of the parents. Additionally, we generated F(2) mice from a cross of the ( P. leucopus outbred x GS16B)F(1). Based on the distribution of telomere length in the F(2) population, we determined that more than five loci contribute to telomere length regulation in Peromyscus. We concluded that inbreeding, through unknown mechanisms, results in the elongation of telomeres, and that telomere length for a given species and/or sub-strain is genetically determined by multiple segregating loci.

Duke Scholars

Published In

Mamm Genome

DOI

ISSN

0938-8990

Publication Date

May 2002

Volume

13

Issue

5

Start / End Page

234 / 238

Location

United States

Related Subject Headings

  • Telomere
  • Peromyscus
  • Leukocytes
  • Inbreeding
  • Genetics & Heredity
  • Crosses, Genetic
  • Animals
  • 3105 Genetics
  • 0604 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
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Manning, E. L., Crossland, J., Dewey, M. J., & Van Zant, G. (2002). Influences of inbreeding and genetics on telomere length in mice. Mamm Genome, 13(5), 234–238. https://doi.org/10.1007/s003350020027
Manning, Erin L., Janet Crossland, Michael J. Dewey, and Gary Van Zant. “Influences of inbreeding and genetics on telomere length in mice.Mamm Genome 13, no. 5 (May 2002): 234–38. https://doi.org/10.1007/s003350020027.
Manning EL, Crossland J, Dewey MJ, Van Zant G. Influences of inbreeding and genetics on telomere length in mice. Mamm Genome. 2002 May;13(5):234–8.
Manning, Erin L., et al. “Influences of inbreeding and genetics on telomere length in mice.Mamm Genome, vol. 13, no. 5, May 2002, pp. 234–38. Pubmed, doi:10.1007/s003350020027.
Manning EL, Crossland J, Dewey MJ, Van Zant G. Influences of inbreeding and genetics on telomere length in mice. Mamm Genome. 2002 May;13(5):234–238.
Journal cover image

Published In

Mamm Genome

DOI

ISSN

0938-8990

Publication Date

May 2002

Volume

13

Issue

5

Start / End Page

234 / 238

Location

United States

Related Subject Headings

  • Telomere
  • Peromyscus
  • Leukocytes
  • Inbreeding
  • Genetics & Heredity
  • Crosses, Genetic
  • Animals
  • 3105 Genetics
  • 0604 Genetics