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Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.

Publication ,  Journal Article
Fluker, M; Grifo, J; Leader, A; Levy, M; Meldrum, D; Muasher, SJ; Rinehart, J; Rosenwaks, Z; Scott, RT; Schoolcraft, W; Shapiro, DB ...
Published in: Fertil Steril
January 2001

OBJECTIVE: To assess the efficacy, safety, and local tolerance of ganirelix acetate for the inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation (COH). DESIGN: Phase III, multicenter, open-label randomized trial. SETTING: In vitro fertilization (IVF) centers in North America. PATIENT(S): Healthy female partners (n = 313) in subfertile couples for whom COH and IVF or intracytoplasmic sperm injection were indicated. INTERVENTION(S): Patients were randomized to receive one COH cycle with ganirelix or the reference treatment, a long protocol of leuprolide acetate in conjunction with follitropin-beta for injection. OUTCOME MEASURE(S): Number of oocytes retrieved, pregnancy rates, endocrine variables, and safety variables. RESULT(S): The mean number of oocytes retrieved per attempt was 11.6 in the ganirelix group and 14.1 in the leuprolide group. Fertilization rates were 62.4% and 61.9% in the ganirelix and leuprolide groups, respectively, and implantation rates were 21.1% and 26.1%. Clinical and ongoing pregnancy rates per attempt were 35.4% and 30.8% in the ganirelix group and 38.4% and 36.4% in the leuprolide acetate group. Fewer moderate and severe injection site reactions were reported with ganirelix (11.9% and 0.6%) than with leuprolide (24.4% and 1.1%). CONCLUSION(S): Ganirelix is effective, safe, and well tolerated. Compared with leuprolide acetate, ganirelix therapy has a shorter duration and fewer injections but produces a similar pregnancy rate.

Duke Scholars

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

January 2001

Volume

75

Issue

1

Start / End Page

38 / 45

Location

United States

Related Subject Headings

  • Stimulation, Chemical
  • Recombinant Proteins
  • Prospective Studies
  • Progesterone
  • Pregnancy
  • Ovary
  • Obstetrics & Reproductive Medicine
  • Leuprolide
  • Humans
  • Hormone Antagonists
 

Citation

APA
Chicago
ICMJE
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Fluker, M., Grifo, J., Leader, A., Levy, M., Meldrum, D., Muasher, S. J., … North American Ganirelix Study Group, . (2001). Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril, 75(1), 38–45. https://doi.org/10.1016/s0015-0282(00)01638-1
Fluker, M., J. Grifo, A. Leader, M. Levy, D. Meldrum, S. J. Muasher, J. Rinehart, et al. “Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.Fertil Steril 75, no. 1 (January 2001): 38–45. https://doi.org/10.1016/s0015-0282(00)01638-1.
Fluker M, Grifo J, Leader A, Levy M, Meldrum D, Muasher SJ, et al. Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril. 2001 Jan;75(1):38–45.
Fluker, M., et al. “Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation.Fertil Steril, vol. 75, no. 1, Jan. 2001, pp. 38–45. Pubmed, doi:10.1016/s0015-0282(00)01638-1.
Fluker M, Grifo J, Leader A, Levy M, Meldrum D, Muasher SJ, Rinehart J, Rosenwaks Z, Scott RT, Schoolcraft W, Shapiro DB, North American Ganirelix Study Group. Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril. 2001 Jan;75(1):38–45.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

January 2001

Volume

75

Issue

1

Start / End Page

38 / 45

Location

United States

Related Subject Headings

  • Stimulation, Chemical
  • Recombinant Proteins
  • Prospective Studies
  • Progesterone
  • Pregnancy
  • Ovary
  • Obstetrics & Reproductive Medicine
  • Leuprolide
  • Humans
  • Hormone Antagonists