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Impact of fertilization history and semen parameters on ICSI outcome.

Publication ,  Journal Article
Mercan, R; Oehninger, S; Muasher, SJ; Toner, JP; Mayer, J; Lanzendorf, SE
Published in: J Assist Reprod Genet
January 1998

PURPOSE: The objectives of this study were (1) to investigate intracytoplasmic sperm injection (ICSI) outcome according to its indications, i.e., a history of failed or poor fertilization and unsuitable sperm parameters for conventional IVF, and (2) to examine the impact of a female's age, sperm concentration, motility, morphology, presence of antisperm antibodies, and hemizona assay (HZA) results on overall outcome. METHODS: Two hundred seventy-nine ICSI cycles performed in 207 couples were retrospectively evaluated. RESULTS: Clinical pregnancy and delivery rates were 36.8 and 29.8% for patients with prior failed fertilization, 23.2 and 17.8% for patients who had prior poor fertilization, and 28.6 and 21.3% for patients with unsuitable sperm parameters. The differences among all groups were found to be insignificant. There was a significant, negative correlation between a female's age and pregnancy results. No difference was found in the three basic sperm parameters between those patients who produced and those who did not produce a pregnancy, but the fertilization rate was significantly higher in patients with more adequate sperm parameters. Although there was a trend toward a better fertilization rate in patients with a hemizona index (HZI) greater than 30 (indicative of a superior sperm-zona pellucida binding capacity) than in those with a HZI less than 30, the difference was not significant. There were no differences in fertilization rate according to the presence or absence of antisperm antibodies. CONCLUSIONS: Fertilization history in a conventional IVF cycle has no effect on success rates following ICSI, and there is no correlation among the basic sperm parameters, the presence of antisperm antibodies, and pregnancy rates.

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Published In

J Assist Reprod Genet

DOI

ISSN

1058-0468

Publication Date

January 1998

Volume

15

Issue

1

Start / End Page

39 / 45

Location

Netherlands

Related Subject Headings

  • Zona Pellucida
  • Treatment Outcome
  • Spermatozoa
  • Sperm Count
  • Semen
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Outcome Assessment, Health Care
  • Obstetrics & Reproductive Medicine
 

Citation

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Mercan, R., Oehninger, S., Muasher, S. J., Toner, J. P., Mayer, J., & Lanzendorf, S. E. (1998). Impact of fertilization history and semen parameters on ICSI outcome. J Assist Reprod Genet, 15(1), 39–45. https://doi.org/10.1023/a:1022578322024
Mercan, R., S. Oehninger, S. J. Muasher, J. P. Toner, J. Mayer, and S. E. Lanzendorf. “Impact of fertilization history and semen parameters on ICSI outcome.J Assist Reprod Genet 15, no. 1 (January 1998): 39–45. https://doi.org/10.1023/a:1022578322024.
Mercan R, Oehninger S, Muasher SJ, Toner JP, Mayer J, Lanzendorf SE. Impact of fertilization history and semen parameters on ICSI outcome. J Assist Reprod Genet. 1998 Jan;15(1):39–45.
Mercan, R., et al. “Impact of fertilization history and semen parameters on ICSI outcome.J Assist Reprod Genet, vol. 15, no. 1, Jan. 1998, pp. 39–45. Pubmed, doi:10.1023/a:1022578322024.
Mercan R, Oehninger S, Muasher SJ, Toner JP, Mayer J, Lanzendorf SE. Impact of fertilization history and semen parameters on ICSI outcome. J Assist Reprod Genet. 1998 Jan;15(1):39–45.
Journal cover image

Published In

J Assist Reprod Genet

DOI

ISSN

1058-0468

Publication Date

January 1998

Volume

15

Issue

1

Start / End Page

39 / 45

Location

Netherlands

Related Subject Headings

  • Zona Pellucida
  • Treatment Outcome
  • Spermatozoa
  • Sperm Count
  • Semen
  • Retrospective Studies
  • Pregnancy Outcome
  • Pregnancy
  • Outcome Assessment, Health Care
  • Obstetrics & Reproductive Medicine