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Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection?

Publication ,  Journal Article
Oehninger, S; Chaturvedi, S; Toner, J; Morshedi, M; Mayer, J; Lanzendorf, S; Muasher, S
Published in: Hum Reprod
August 1998

The objective of this study was to investigate the role of the spermatozoon (paternal effects) on implantation and pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Male individuals of three types were analysed: infertile men with oligoasthenoteratozoospermia (OAT), infertile men with normozoospermia and fertile men (donors). Female counterparts were judged to have comparable egg quality within two groups studied, i.e. infertile women with pure mechanical (tubal) infertility and recipients of donor eggs. There were significantly higher differences in implantation and pregnancy rates in groups using donor spermatozoa and donor egg recipients. Analyses of key set groups revealed a trend toward a poorer implantation and pregnancy outcome when comparing OAT versus normozoospermic patients within IVF, but not within ICSI treatments, in couples with tubal infertility. In couples who were recipients of donor eggs, no differences were observed between OAT patients treated by ICSI and normozoospermic patients treated with IVF. No significant differences were observed in miscarriage rates within any groups studied. In conclusion, the poorer results observed in OAT patients undergoing IVF may be secondary to spermatozoal effects due to a high insemination concentration. Overall, there does not seem to be a significant effect of severe male infertility (OAT) on implantation and pregnancy outcome. However, this does not preclude that specific sperm aberrations may exert a negative effect on embryogenesis and therefore on implantation potential following assisted or in-vivo reproduction.

Duke Scholars

Published In

Hum Reprod

DOI

ISSN

0268-1161

Publication Date

August 1998

Volume

13

Issue

8

Start / End Page

2161 / 2164

Location

England

Related Subject Headings

  • Spermatozoa
  • Pregnancy Outcome
  • Pregnancy
  • Oocyte Donation
  • Obstetrics & Reproductive Medicine
  • Microinjections
  • Male
  • Infertility, Male
  • Infertility, Female
  • Humans
 

Citation

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Oehninger, S., Chaturvedi, S., Toner, J., Morshedi, M., Mayer, J., Lanzendorf, S., & Muasher, S. (1998). Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection? Hum Reprod, 13(8), 2161–2164. https://doi.org/10.1093/humrep/13.8.2161
Oehninger, S., S. Chaturvedi, J. Toner, M. Morshedi, J. Mayer, S. Lanzendorf, and S. Muasher. “Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection?Hum Reprod 13, no. 8 (August 1998): 2161–64. https://doi.org/10.1093/humrep/13.8.2161.
Oehninger S, Chaturvedi S, Toner J, Morshedi M, Mayer J, Lanzendorf S, et al. Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection? Hum Reprod. 1998 Aug;13(8):2161–4.
Oehninger, S., et al. “Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection?Hum Reprod, vol. 13, no. 8, Aug. 1998, pp. 2161–64. Pubmed, doi:10.1093/humrep/13.8.2161.
Oehninger S, Chaturvedi S, Toner J, Morshedi M, Mayer J, Lanzendorf S, Muasher S. Semen quality: is there a paternal effect on pregnancy outcome in in-vitro fertilization/intracytoplasmic sperm injection? Hum Reprod. 1998 Aug;13(8):2161–2164.
Journal cover image

Published In

Hum Reprod

DOI

ISSN

0268-1161

Publication Date

August 1998

Volume

13

Issue

8

Start / End Page

2161 / 2164

Location

England

Related Subject Headings

  • Spermatozoa
  • Pregnancy Outcome
  • Pregnancy
  • Oocyte Donation
  • Obstetrics & Reproductive Medicine
  • Microinjections
  • Male
  • Infertility, Male
  • Infertility, Female
  • Humans