Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients.

Publication ,  Journal Article
Karande, VC; Jones, GS; Veeck, LL; Muasher, SJ
Published in: Fertil Steril
March 1990

In an attempt to improve their outcome with in vitro fertilization (IVF), 34 low-responder patients were stimulated with six ampules of follicle-stimulating hormone (FSH) daily starting on day 1 (n = 17) or day 2 (n = 17) of their menstrual cycles. The stimulated cycles showed a mean peak estradiol of 443 +/- 173 pg/mL, mean days of human chorionic gonadotropin of 7.6 +/- 1.4, 2.67 +/- 1.5 preovulatory oocytes per retrieval, and 2.56 +/- 1.3 oocytes per transfer. Three clinical pregnancies resulted after 25 embryo transfer cycles (12%). With paired analysis, we compared 8 patient cycles with prior six ampules of FSH stimulation starting on day 3; all parameters examined showed no significant differences. In a comparison of 22 patient cycles with prior 4 ampules of FSH stimulation on cycle day 3, no significant differences in any parameters were observed except in the higher number of ampules used in the present study. We conclude that high-dose FSH stimulation at the onset of the menstrual cycle does not improve the IVF outcome in low-responder patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

March 1990

Volume

53

Issue

3

Start / End Page

486 / 489

Location

United States

Related Subject Headings

  • Pregnancy Outcome
  • Pregnancy
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female
  • Estradiol
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Karande, V. C., Jones, G. S., Veeck, L. L., & Muasher, S. J. (1990). High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients. Fertil Steril, 53(3), 486–489. https://doi.org/10.1016/s0015-0282(16)53345-7
Karande, V. C., G. S. Jones, L. L. Veeck, and S. J. Muasher. “High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients.Fertil Steril 53, no. 3 (March 1990): 486–89. https://doi.org/10.1016/s0015-0282(16)53345-7.
Karande, V. C., et al. “High-dose follicle-stimulating hormone stimulation at the onset of the menstrual cycle does not improve the in vitro fertilization outcome in low-responder patients.Fertil Steril, vol. 53, no. 3, Mar. 1990, pp. 486–89. Pubmed, doi:10.1016/s0015-0282(16)53345-7.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

March 1990

Volume

53

Issue

3

Start / End Page

486 / 489

Location

United States

Related Subject Headings

  • Pregnancy Outcome
  • Pregnancy
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female
  • Estradiol