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The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome.

Publication ,  Journal Article
Muasher, SJ; Oehninger, S; Simonetti, S; Matta, J; Ellis, LM; Liu, HC; Jones, GS; Rosenwaks, Z
Published in: Fertil Steril
August 1988

The purpose of this study was to determine whether basal or stimulated (or both) serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on day 3 of the cycle before administration of exogenous gonadotropins can predict stimulation response and in vitro fertilization (IVF) outcome. Eighty consecutive new patients underwent a gonadotropin-releasing hormone (GnRH) stimulation test on the morning of cycle day 3. All patients underwent the same stimulation protocol consisting of a combination of FSH and human menopausal gonadotropin (hMG). Paired discriminant analysis of FSH0 (at 0 minutes from GnRH injection) and LH0 revealed seven distinct groups of patients with statistically significant differences among the means: groups 1, 2, and 3 (26.25%) with higher means FSH0:LH0; group 4 (40%) with mean FSH0:LH0 (both levels less than 10 mIU/ml) of 1:1, and groups 5, 6, and 7 (33.75%) with higher mean LH0:FSH0. Canonical discriminant analysis of both basal and stimulated serum FSH and LH levels confirmed the seven groups and did not add to the information from analysis of FSH0 and LH0 only. Serum estradiol (E2) response during stimulation, as well as the number of preovulatory oocytes aspirated and transferred, was highest in the groups with a higher mean LH0:FSH0, intermediate in the group with mean FSH0:LH0 of 1:1, and lowest in the group with a higher mean FSH0:LH0. No pregnancy occurred in the higher FSH:LH groups. It is concluded that basal serum gonadotropin levels can distinguish different populations of IVF patients who tend to behave differently in terms of E2 response, oocytes obtained and transferred, and pregnancy rates and outcome.

Duke Scholars

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Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

August 1988

Volume

50

Issue

2

Start / End Page

298 / 307

Location

United States

Related Subject Headings

  • Progesterone
  • Pregnancy
  • Pituitary Hormone-Releasing Hormones
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Menotropins
  • Luteinizing Hormone
  • Infertility
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Muasher, S. J., Oehninger, S., Simonetti, S., Matta, J., Ellis, L. M., Liu, H. C., … Rosenwaks, Z. (1988). The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril, 50(2), 298–307. https://doi.org/10.1016/s0015-0282(16)60077-8
Muasher, S. J., S. Oehninger, S. Simonetti, J. Matta, L. M. Ellis, H. C. Liu, G. S. Jones, and Z. Rosenwaks. “The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome.Fertil Steril 50, no. 2 (August 1988): 298–307. https://doi.org/10.1016/s0015-0282(16)60077-8.
Muasher SJ, Oehninger S, Simonetti S, Matta J, Ellis LM, Liu HC, et al. The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril. 1988 Aug;50(2):298–307.
Muasher, S. J., et al. “The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome.Fertil Steril, vol. 50, no. 2, Aug. 1988, pp. 298–307. Pubmed, doi:10.1016/s0015-0282(16)60077-8.
Muasher SJ, Oehninger S, Simonetti S, Matta J, Ellis LM, Liu HC, Jones GS, Rosenwaks Z. The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril. 1988 Aug;50(2):298–307.
Journal cover image

Published In

Fertil Steril

DOI

ISSN

0015-0282

Publication Date

August 1988

Volume

50

Issue

2

Start / End Page

298 / 307

Location

United States

Related Subject Headings

  • Progesterone
  • Pregnancy
  • Pituitary Hormone-Releasing Hormones
  • Oocytes
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Menotropins
  • Luteinizing Hormone
  • Infertility
  • Humans