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ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY.

Publication ,  Journal Article
Prasad, G; Jahanshad, N; Aganj, I; Lenglet, C; Sapiro, G; Toga, AW; Thompson, PM
Published in: Proceedings. IEEE International Symposium on Biomedical Imaging
April 2011

High angular resolution diffusion imaging (HARDI) allows in vivo analysis of the white matter structure and connectivity. Based on orientation distribution functions (ODFs) that represent the directionality of water diffusion at each point in the brain, tractography methods can recover major axonal pathways. This enables tract-based analysis of fiber integrity and connectivity. For multi-subject comparisons, fibers may be clustered into bundles that are consistently found across subjects. To do this, we scanned 20 young adults with HARDI at 4 T. From the reconstructed ODFs, we performed whole-brain tractography with a novel Hough transform method. We then used measures of agreement between the extracted 3D curves and a co-registered probabilistic DTI atlas to select key pathways. Using median filtering and a shortest path graph search, we derived the maximum density path to compactly represent each tract in the population. With this tract-based method, we performed tract-based analysis of fractional anisotropy, and assessed how the chosen tractography algorithm influenced the results. The resulting method may expedite population-based statistical analysis of HARDI and DTI.

Duke Scholars

Published In

Proceedings. IEEE International Symposium on Biomedical Imaging

DOI

EISSN

1945-8452

ISSN

1945-7928

Publication Date

April 2011

Volume

2011

Start / End Page

276 / 280
 

Citation

APA
Chicago
ICMJE
MLA
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Prasad, G., Jahanshad, N., Aganj, I., Lenglet, C., Sapiro, G., Toga, A. W., & Thompson, P. M. (2011). ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY. Proceedings. IEEE International Symposium on Biomedical Imaging, 2011, 276–280. https://doi.org/10.1109/isbi.2011.5872405
Prasad, Gautam, Neda Jahanshad, Iman Aganj, Christophe Lenglet, Guillermo Sapiro, Arthur W. Toga, and Paul M. Thompson. “ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY.Proceedings. IEEE International Symposium on Biomedical Imaging 2011 (April 2011): 276–80. https://doi.org/10.1109/isbi.2011.5872405.
Prasad G, Jahanshad N, Aganj I, Lenglet C, Sapiro G, Toga AW, et al. ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY. Proceedings IEEE International Symposium on Biomedical Imaging. 2011 Apr;2011:276–80.
Prasad, Gautam, et al. “ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY.Proceedings. IEEE International Symposium on Biomedical Imaging, vol. 2011, Apr. 2011, pp. 276–80. Epmc, doi:10.1109/isbi.2011.5872405.
Prasad G, Jahanshad N, Aganj I, Lenglet C, Sapiro G, Toga AW, Thompson PM. ATLAS-BASED FIBER CLUSTERING FOR MULTI-SUBJECT ANALYSIS OF HIGH ANGULAR RESOLUTION DIFFUSION IMAGING TRACTOGRAPHY. Proceedings IEEE International Symposium on Biomedical Imaging. 2011 Apr;2011:276–280.

Published In

Proceedings. IEEE International Symposium on Biomedical Imaging

DOI

EISSN

1945-8452

ISSN

1945-7928

Publication Date

April 2011

Volume

2011

Start / End Page

276 / 280