
High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity.
Publication
, Journal Article
Jones, RB; Shpall, EJ; Ross, M; Coniglio, D; Affronti, ML; Peters, WP
Published in: Cancer Chemother Pharmacol
1990
Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe veno-occlusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m2) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential.
Duke Scholars
Published In
Cancer Chemother Pharmacol
DOI
ISSN
0344-5704
Publication Date
1990
Volume
26
Issue
2
Start / End Page
155 / 156
Location
Germany
Related Subject Headings
- Organoplatinum Compounds
- Oncology & Carcinogenesis
- Melanoma
- Humans
- Hepatic Veno-Occlusive Disease
- Female
- Cyclophosphamide
- Combined Modality Therapy
- Carmustine
- Carboplatin
Citation
APA
Chicago
ICMJE
MLA
NLM
Jones, R. B., Shpall, E. J., Ross, M., Coniglio, D., Affronti, M. L., & Peters, W. P. (1990). High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity. Cancer Chemother Pharmacol, 26(2), 155–156. https://doi.org/10.1007/BF02897264
Jones, R. B., E. J. Shpall, M. Ross, D. Coniglio, M. L. Affronti, and W. P. Peters. “High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity.” Cancer Chemother Pharmacol 26, no. 2 (1990): 155–56. https://doi.org/10.1007/BF02897264.
Jones RB, Shpall EJ, Ross M, Coniglio D, Affronti ML, Peters WP. High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity. Cancer Chemother Pharmacol. 1990;26(2):155–6.
Jones, R. B., et al. “High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity.” Cancer Chemother Pharmacol, vol. 26, no. 2, 1990, pp. 155–56. Pubmed, doi:10.1007/BF02897264.
Jones RB, Shpall EJ, Ross M, Coniglio D, Affronti ML, Peters WP. High-dose carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity. Cancer Chemother Pharmacol. 1990;26(2):155–156.

Published In
Cancer Chemother Pharmacol
DOI
ISSN
0344-5704
Publication Date
1990
Volume
26
Issue
2
Start / End Page
155 / 156
Location
Germany
Related Subject Headings
- Organoplatinum Compounds
- Oncology & Carcinogenesis
- Melanoma
- Humans
- Hepatic Veno-Occlusive Disease
- Female
- Cyclophosphamide
- Combined Modality Therapy
- Carmustine
- Carboplatin