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Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.

Publication ,  Journal Article
Diabetic Retinopathy Clinical Research Network, ; Brucker, AJ; Qin, H; Antoszyk, AN; Beck, RW; Bressler, NM; Browning, DJ; Elman, MJ; Gross, JG ...
Published in: Arch Ophthalmol
February 2009

OBJECTIVE: To compare the effects of single-sitting vs 4-sitting panretinal photocoagulation (PRP) on macular edema in subjects with severe nonproliferative or early proliferative diabetic retinopathy with relatively good visual acuity and no or mild center-involved macular edema. METHODS: Subjects were treated with 1 sitting or 4 sittings of PRP in a nonrandomized, prospective, multicentered clinical trial. Main Outcome Measure Central subfield thickness on optical coherence tomography (OCT). RESULTS: Central subfield thickness was slightly greater in the 1-sitting group (n = 84) than in the 4-sitting group (n = 71) at the 3-day (P = .01) and 4-week visits (P = .003). At the 34-week primary outcome visit, the slight differences had reversed, with the thickness being slightly greater in the 4-sitting group than in the 1-sitting group (P = .06). Visual acuity differences paralleled OCT differences. CONCLUSIONS: Our results suggest that clinically meaningful differences are unlikely in OCT thickness or visual acuity following application of PRP in 1 sitting compared with 4 sittings in subjects in this cohort. More definitive results would require a large randomized trial. Application to Clinical Practice These results suggest PRP costs to some patients in terms of travel and lost productivity as well as to eye care providers could be reduced. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00687154.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

February 2009

Volume

127

Issue

2

Start / End Page

132 / 140

Location

United States

Related Subject Headings

  • Visual Acuity
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retreatment
  • Retina
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema
 

Citation

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Diabetic Retinopathy Clinical Research Network, ., Brucker, A. J., Qin, H., Antoszyk, A. N., Beck, R. W., Bressler, N. M., … Wells, J. A. (2009). Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings. Arch Ophthalmol, 127(2), 132–140. https://doi.org/10.1001/archophthalmol.2008.565
Diabetic Retinopathy Clinical Research Network, John A., Alexander J. Brucker, Haijing Qin, Andrew N. Antoszyk, Roy W. Beck, Neil M. Bressler, David J. Browning, et al. “Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.Arch Ophthalmol 127, no. 2 (February 2009): 132–40. https://doi.org/10.1001/archophthalmol.2008.565.
Diabetic Retinopathy Clinical Research Network, Brucker AJ, Qin H, Antoszyk AN, Beck RW, Bressler NM, et al. Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings. Arch Ophthalmol. 2009 Feb;127(2):132–40.
Diabetic Retinopathy Clinical Research Network, John A., et al. “Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.Arch Ophthalmol, vol. 127, no. 2, Feb. 2009, pp. 132–40. Pubmed, doi:10.1001/archophthalmol.2008.565.
Diabetic Retinopathy Clinical Research Network, Brucker AJ, Qin H, Antoszyk AN, Beck RW, Bressler NM, Browning DJ, Elman MJ, Glassman AR, Gross JG, Kollman C, Wells JA. Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings. Arch Ophthalmol. 2009 Feb;127(2):132–140.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

February 2009

Volume

127

Issue

2

Start / End Page

132 / 140

Location

United States

Related Subject Headings

  • Visual Acuity
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retreatment
  • Retina
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Edema