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Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model.

Publication ,  Journal Article
Davenport, MS; Heye, T; Dale, BM; Horvath, JJ; Breault, SR; Feuerlein, S; Bashir, MR; Boll, DT; Merkle, EM
Published in: J Magn Reson Imaging
August 2013

PURPOSE: To determine the reproducibility of TWIST-derived (Time-Resolved Angiography with Interleaved Stochastic Trajectories) quantitative dynamic contrast enhanced (DCE) MRI in a uterine fibroid model. MATERIALS AND METHODS: The institutional review board approved this retrospective study. Dynamic contrast-enhanced TWIST datasets from 15 randomly selected 1.5 Tesla pelvic MR studies were postprocessed. Five readers recorded kinetic parameters (K(trans) [volume transfer constant], ve [extracellular extravascular space volume], kep [flux rate constant], iAUC [initial area under the gadolinium-time curve]) of the largest uterine fibroid using three region-of-interest (ROI) selection methods. Measurements were randomized and repeated three times, and measures of reproducibility were calculated. RESULTS: The intra-rater coefficients of variation (CVs, brackets indicate 95% confidence intervals) varied from 4.6% to 7.6% (K(trans) 7.6% [6.1%, 9.1%], kep 7.2% [5.9%, 8.5%], ve 4.6% [3.8%, 5.4%], and iAUC 7.2% [6.1%, 8.3%]). ve was the most reproducible (P < 0.05). Inter-rater reproducibility was significantly (P < 0.05) greater for the large ROI method (range of intraclass correlation coefficients [ICCs] = 0.80-0.98 versus 0.48-0.63 [user-defined ROI] versus 0.41-0.69 [targeted ROI]). The uterine fibroid accounted for the greatest fraction of variance for the large ROI method (range across kinetic parameters: 83-98% versus 56-69% [user-defined ROI] versus 47-74% [targeted ROI]). The reader accounted for the greatest fraction of variance for the user-defined ROI method (0.4-14.1% versus 0.1-3.0% [large ROI] versus <0.1-1.5% [targeted ROI]). CONCLUSION: Changes in TWIST-derived DCE-MRI kinetic parameters of up to 9-15% may be attributable to measurement error. Large DCE-MRI regions of interest are the most reproducible across multiple readers.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

August 2013

Volume

38

Issue

2

Start / End Page

329 / 335

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Organometallic Compounds
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic
  • Middle Aged
  • Meglumine
  • Magnetic Resonance Angiography
 

Citation

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ICMJE
MLA
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Davenport, M. S., Heye, T., Dale, B. M., Horvath, J. J., Breault, S. R., Feuerlein, S., … Merkle, E. M. (2013). Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. J Magn Reson Imaging, 38(2), 329–335. https://doi.org/10.1002/jmri.23974
Davenport, Matthew S., Tobias Heye, Brian M. Dale, Jeffrey J. Horvath, Steven R. Breault, Sebastian Feuerlein, Mustafa R. Bashir, Daniel T. Boll, and Elmar M. Merkle. “Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model.J Magn Reson Imaging 38, no. 2 (August 2013): 329–35. https://doi.org/10.1002/jmri.23974.
Davenport MS, Heye T, Dale BM, Horvath JJ, Breault SR, Feuerlein S, et al. Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. J Magn Reson Imaging. 2013 Aug;38(2):329–35.
Davenport, Matthew S., et al. “Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model.J Magn Reson Imaging, vol. 38, no. 2, Aug. 2013, pp. 329–35. Pubmed, doi:10.1002/jmri.23974.
Davenport MS, Heye T, Dale BM, Horvath JJ, Breault SR, Feuerlein S, Bashir MR, Boll DT, Merkle EM. Inter- and intra-rater reproducibility of quantitative dynamic contrast enhanced MRI using TWIST perfusion data in a uterine fibroid model. J Magn Reson Imaging. 2013 Aug;38(2):329–335.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

August 2013

Volume

38

Issue

2

Start / End Page

329 / 335

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Organometallic Compounds
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Neovascularization, Pathologic
  • Middle Aged
  • Meglumine
  • Magnetic Resonance Angiography