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Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium.

Publication ,  Journal Article
Agarwal, SK; Ayyash, L; Gourley, CS; Levy, J; Faber, K; Hughes, CL
Published in: Food Chem Toxicol
January 1996

Two experiments evaluating functional endpoints pertaining to the developmental neuroendocrine effects of aluminum in the rat are reported. A total of 31 timed mated dams were fed by daily gastric gavage 0, 5, 25, 50, 250, 500 or 1000 mg/kg body weight/day aluminum as a solution of aluminum lactate in distilled water from days 5 to 15 of gestation. The 390 offspring were evaluated for morphological and physiological parameters of reproductive functioning, including birth weight, anogenital distance (AGD), timing of vaginal opening, regularly of oestrous cycles, duration of pseudopregnancy (PSP), number of superovulated oocytes, and gonadal weight. No consistent or reproducible findings suggestive of toxic effect were found in the parameters of birth weight, AGD, timing of vaginal opening, duration of PSP, number of superovulated oocytes, and adult gonadal weight. A temporary increase in the proportion of aberrant oestrous cycles was detected during the first four cycles after vaginal opening, in the 250 mg/body weight/day group, with none by the fifth consecutive oestrous cycle. These results suggest that, apart from a transient disturbance of oestrous cycle regularity, aluminum does not have a developmental reproductive toxic effect.

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Published In

Food Chem Toxicol

DOI

ISSN

0278-6915

Publication Date

January 1996

Volume

34

Issue

1

Start / End Page

49 / 53

Location

England

Related Subject Headings

  • Testis
  • Sexual Maturation
  • Reproduction
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Organ Size
  • Neurosecretory Systems
  • Male
  • Genitalia
 

Citation

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Agarwal, S. K., Ayyash, L., Gourley, C. S., Levy, J., Faber, K., & Hughes, C. L. (1996). Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. Food Chem Toxicol, 34(1), 49–53. https://doi.org/10.1016/0278-6915(95)00088-7
Agarwal, S. K., L. Ayyash, C. S. Gourley, J. Levy, K. Faber, and C. L. Hughes. “Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium.Food Chem Toxicol 34, no. 1 (January 1996): 49–53. https://doi.org/10.1016/0278-6915(95)00088-7.
Agarwal SK, Ayyash L, Gourley CS, Levy J, Faber K, Hughes CL. Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. Food Chem Toxicol. 1996 Jan;34(1):49–53.
Agarwal, S. K., et al. “Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium.Food Chem Toxicol, vol. 34, no. 1, Jan. 1996, pp. 49–53. Pubmed, doi:10.1016/0278-6915(95)00088-7.
Agarwal SK, Ayyash L, Gourley CS, Levy J, Faber K, Hughes CL. Evaluation of the developmental neuroendocrine and reproductive toxicology of aluminium. Food Chem Toxicol. 1996 Jan;34(1):49–53.
Journal cover image

Published In

Food Chem Toxicol

DOI

ISSN

0278-6915

Publication Date

January 1996

Volume

34

Issue

1

Start / End Page

49 / 53

Location

England

Related Subject Headings

  • Testis
  • Sexual Maturation
  • Reproduction
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Organ Size
  • Neurosecretory Systems
  • Male
  • Genitalia