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Transdermal iontophoretic peptide delivery: in vitro and in vivo studies with luteinizing hormone releasing hormone.

Publication ,  Journal Article
Heit, MC; Williams, PL; Jayes, FL; Chang, SK; Riviere, JE
Published in: J Pharm Sci
May 1993

Protein and peptide drugs are not orally active. Their large molecular size and charged character make them poor candidates for passive transdermal delivery. With an applied electromotive force, these drugs can be forced through the skin to be absorbed by the systemic circulation. The present study investigates the transdermal iontophoretic delivery of a peptide hormone in an in vitro model system, the isolated perfused porcine skin flap, as well as in vivo. It is shown that with knowledge of the systemic disposition of the drug, transdermal fluxes can be utilized to accurately predict in vivo serum concentrations. It is also shown that the iontophoretically delivered hormone retains both its immunologic and biologic activity.

Duke Scholars

Published In

J Pharm Sci

DOI

ISSN

0022-3549

Publication Date

May 1993

Volume

82

Issue

5

Start / End Page

240 / 243

Location

United States

Related Subject Headings

  • Swine
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Luteinizing Hormone
  • Iontophoresis
  • Injections, Intravenous
  • Gonadotropin-Releasing Hormone
  • Follicle Stimulating Hormone
  • Female
  • Animals
 

Citation

APA
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ICMJE
MLA
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Heit, M. C., Williams, P. L., Jayes, F. L., Chang, S. K., & Riviere, J. E. (1993). Transdermal iontophoretic peptide delivery: in vitro and in vivo studies with luteinizing hormone releasing hormone. J Pharm Sci, 82(5), 240–243. https://doi.org/10.1002/jps.2600820529
Journal cover image

Published In

J Pharm Sci

DOI

ISSN

0022-3549

Publication Date

May 1993

Volume

82

Issue

5

Start / End Page

240 / 243

Location

United States

Related Subject Headings

  • Swine
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Luteinizing Hormone
  • Iontophoresis
  • Injections, Intravenous
  • Gonadotropin-Releasing Hormone
  • Follicle Stimulating Hormone
  • Female
  • Animals