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Hypoparathyroidism: a possible cause of osteomalacia .

Publication ,  Journal Article
Drezner, MK; Neelon, FA; Jowsey, J; Lebovitz, HE
Published in: J Clin Endocrinol Metab
July 1977

A 17 year old man with longstanding hypocalcemia and hyperphosphatemia presented with incapacitating bone pain and progressive weakness nad bowing of the legs. The serum abnormalities were due to idiopathic hypoparathyroidism as evidenced by a decreased serum concentration of parathyroid hormone and an appropriate rise in urinary cyclic AMP and phosphate excretion, and serum calcium concentration, in response to exogenously administered parathyroid extract. The serum concentration of 1,25-dihydroxycholecalciferol was appropriately decreased. The bone findings were due to osteomalacia as documented by physical findings, bone roentgenograms, and bone biopsy. Normal renal tubular function, blood pH, and serum concentration of 25-hydroxycholecalciferol and elevated serum alkaline phosphatase excluded the common causes of osteomalacia. The data are consistent with the hypothsis that lack of parathyroid hormone causes both hypocalcemia and a decreased serum concentration of 1,25-dihydroxycholecalciferol which, in turn, limit the availability of calcium and cause defective synthesis of bone matrix resulting in abnormal mineralization.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

July 1977

Volume

45

Issue

1

Start / End Page

114 / 122

Location

United States

Related Subject Headings

  • Phosphorus
  • Parathyroid Hormone
  • Osteomalacia
  • Male
  • Hypoparathyroidism
  • Hydroxycholecalciferols
  • Humans
  • Endocrinology & Metabolism
  • Dihydroxycholecalciferols
  • Calcium
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Drezner, M. K., Neelon, F. A., Jowsey, J., & Lebovitz, H. E. (1977). Hypoparathyroidism: a possible cause of osteomalacia . J Clin Endocrinol Metab, 45(1), 114–122. https://doi.org/10.1210/jcem-45-1-114
Drezner, M. K., F. A. Neelon, J. Jowsey, and H. E. Lebovitz. “Hypoparathyroidism: a possible cause of osteomalacia .J Clin Endocrinol Metab 45, no. 1 (July 1977): 114–22. https://doi.org/10.1210/jcem-45-1-114.
Drezner MK, Neelon FA, Jowsey J, Lebovitz HE. Hypoparathyroidism: a possible cause of osteomalacia . J Clin Endocrinol Metab. 1977 Jul;45(1):114–22.
Drezner, M. K., et al. “Hypoparathyroidism: a possible cause of osteomalacia .J Clin Endocrinol Metab, vol. 45, no. 1, July 1977, pp. 114–22. Pubmed, doi:10.1210/jcem-45-1-114.
Drezner MK, Neelon FA, Jowsey J, Lebovitz HE. Hypoparathyroidism: a possible cause of osteomalacia . J Clin Endocrinol Metab. 1977 Jul;45(1):114–122.

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

July 1977

Volume

45

Issue

1

Start / End Page

114 / 122

Location

United States

Related Subject Headings

  • Phosphorus
  • Parathyroid Hormone
  • Osteomalacia
  • Male
  • Hypoparathyroidism
  • Hydroxycholecalciferols
  • Humans
  • Endocrinology & Metabolism
  • Dihydroxycholecalciferols
  • Calcium