Skip to main content
Journal cover image

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.

Publication ,  Journal Article
Hunt, CM; Watkins, PB; Saenger, P; Stave, GM; Barlascini, N; Watlington, CO; Wright, JT; Guzelian, PS
Published in: Clin Pharmacol Ther
January 1992

The N-demethylation of erythromycin and 6 beta-hydroxylation of cortisol are both functions of the glucocorticoid-inducible CYP3A in human liver microsomes. To determine whether 6 beta-hydroxylation and erythromycin N-demethylation are catalyzed by similar or distinct CYP3A isoforms, erythromycin N-demethylase activity, as reflected by the recently described 14[C]-erythromycin breath test, was compared with urinary 6 beta-hydroxycortisol/cortisol ratios, a measure of cortisol 6 beta-hydroxylase activity, in nine patients. Erythromycin N-demethylation varied fourfold and 6 beta-hydroxycortisol/cortisol ratios varied sevenfold among the subjects; no correlation was found between these activities (r2 = 0.065). New noninvasive tests of CYP3A strongly suggest cortisol 6 beta-hydroxylation and erythromycin N-demethylation are performed by distinct CYP3A isoforms.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1992

Volume

51

Issue

1

Start / End Page

18 / 23

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pharmacology & Pharmacy
  • Middle Aged
  • Methylation
  • Male
  • Liver
  • Isoenzymes
  • Hypertension
  • Hydroxylation
  • Hydrocortisone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hunt, C. M., Watkins, P. B., Saenger, P., Stave, G. M., Barlascini, N., Watlington, C. O., … Guzelian, P. S. (1992). Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. Clin Pharmacol Ther, 51(1), 18–23. https://doi.org/10.1038/clpt.1992.3
Hunt, C. M., P. B. Watkins, P. Saenger, G. M. Stave, N. Barlascini, C. O. Watlington, J. T. Wright, and P. S. Guzelian. “Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.Clin Pharmacol Ther 51, no. 1 (January 1992): 18–23. https://doi.org/10.1038/clpt.1992.3.
Hunt CM, Watkins PB, Saenger P, Stave GM, Barlascini N, Watlington CO, et al. Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. Clin Pharmacol Ther. 1992 Jan;51(1):18–23.
Hunt, C. M., et al. “Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.Clin Pharmacol Ther, vol. 51, no. 1, Jan. 1992, pp. 18–23. Pubmed, doi:10.1038/clpt.1992.3.
Hunt CM, Watkins PB, Saenger P, Stave GM, Barlascini N, Watlington CO, Wright JT, Guzelian PS. Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. Clin Pharmacol Ther. 1992 Jan;51(1):18–23.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1992

Volume

51

Issue

1

Start / End Page

18 / 23

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pharmacology & Pharmacy
  • Middle Aged
  • Methylation
  • Male
  • Liver
  • Isoenzymes
  • Hypertension
  • Hydroxylation
  • Hydrocortisone