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Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia.

Publication ,  Journal Article
Dyer, RS; Burden, E; Hulebak, K; Schultz, N; Swartzwelder, HS; Annau, Z
Published in: Neurobehav Toxicol
1979

A series of experiments was performed to examine the utility of using the properties of artifically induced seizures as indices of the toxic effect of CO upon the CNS. The two behavioral seizure models tested, 6 Hz ECS and pentylenetetrazol, were unable to differentiate between exposed and unexposed animals, even at severe concentrations of CO (55% HbCO). On the other hand, the hippocampal afterdischarge (AD) proved to be at least as sensitive as the visual evoked potential method. There was a CO concentration-dependent shift in the AD type. CO increased the probability of occurrence of post-ictal depressions (PIDs) without rebound ADs, an event never seen in control animals. CO also decreased the spike frequency within ADs in a dose-dependent manner.

Duke Scholars

Published In

Neurobehav Toxicol

ISSN

0191-3581

Publication Date

1979

Volume

1

Issue

1

Start / End Page

21 / 25

Location

United States

Related Subject Headings

  • Seizures
  • Rats
  • Pentylenetetrazole
  • Male
  • Hippocampus
  • Hemoglobins
  • Electric Stimulation
  • Carbon Monoxide Poisoning
  • Animals
 

Citation

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Dyer, R. S., Burden, E., Hulebak, K., Schultz, N., Swartzwelder, H. S., & Annau, Z. (1979). Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia. Neurobehav Toxicol, 1(1), 21–25.
Dyer, R. S., E. Burden, K. Hulebak, N. Schultz, H. S. Swartzwelder, and Z. Annau. “Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia.Neurobehav Toxicol 1, no. 1 (1979): 21–25.
Dyer RS, Burden E, Hulebak K, Schultz N, Swartzwelder HS, Annau Z. Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia. Neurobehav Toxicol. 1979;1(1):21–5.
Dyer, R. S., et al. “Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia.Neurobehav Toxicol, vol. 1, no. 1, 1979, pp. 21–25.
Dyer RS, Burden E, Hulebak K, Schultz N, Swartzwelder HS, Annau Z. Hippocampal afterdischarges and their post-ictal sequelae in rats: effects of carbon monoxide hypoxia. Neurobehav Toxicol. 1979;1(1):21–25.

Published In

Neurobehav Toxicol

ISSN

0191-3581

Publication Date

1979

Volume

1

Issue

1

Start / End Page

21 / 25

Location

United States

Related Subject Headings

  • Seizures
  • Rats
  • Pentylenetetrazole
  • Male
  • Hippocampus
  • Hemoglobins
  • Electric Stimulation
  • Carbon Monoxide Poisoning
  • Animals