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The mechanisms underlying the spatial spreading of signaling activity.

Publication ,  Journal Article
Yasuda, R; Murakoshi, H
Published in: Curr Opin Neurobiol
April 2011

During the induction of plasticity of dendritic spines, many intracellular signaling pathways are spatially and temporally regulated to co-ordinate downstream cellular processes in different dendritic micron-domains. Recent advent of imaging technology based on fluorescence resonance energy transfer (FRET) has allowed the direct monitoring of the spatiotemporal regulation of signaling activity in spines and dendrites during synaptic plasticity. In particular, the activity of three small GTPase proteins HRas, Cdc42, and RhoA, which share similar structure and mobility on the plasma membrane, displayed different spatial spreading patterns: Cdc42 is compartmentalized in the stimulated spines while RhoA and HRas spread into dendrites over 5-10 μm. These measurements thus provide the basis for understanding the mechanisms underlying the spatiotemporal regulation of signaling activity. Further, using spatiotemporally controlled spine stimulations, some of the roles of signal spreading have been revealed.

Duke Scholars

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

April 2011

Volume

21

Issue

2

Start / End Page

313 / 321

Location

England

Related Subject Headings

  • Synaptic Transmission
  • Neuronal Plasticity
  • Humans
  • Dendritic Spines
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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MLA
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Yasuda, R., & Murakoshi, H. (2011). The mechanisms underlying the spatial spreading of signaling activity. Curr Opin Neurobiol, 21(2), 313–321. https://doi.org/10.1016/j.conb.2011.02.008
Yasuda, Ryohei, and Hideji Murakoshi. “The mechanisms underlying the spatial spreading of signaling activity.Curr Opin Neurobiol 21, no. 2 (April 2011): 313–21. https://doi.org/10.1016/j.conb.2011.02.008.
Yasuda R, Murakoshi H. The mechanisms underlying the spatial spreading of signaling activity. Curr Opin Neurobiol. 2011 Apr;21(2):313–21.
Yasuda, Ryohei, and Hideji Murakoshi. “The mechanisms underlying the spatial spreading of signaling activity.Curr Opin Neurobiol, vol. 21, no. 2, Apr. 2011, pp. 313–21. Pubmed, doi:10.1016/j.conb.2011.02.008.
Yasuda R, Murakoshi H. The mechanisms underlying the spatial spreading of signaling activity. Curr Opin Neurobiol. 2011 Apr;21(2):313–321.
Journal cover image

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

April 2011

Volume

21

Issue

2

Start / End Page

313 / 321

Location

England

Related Subject Headings

  • Synaptic Transmission
  • Neuronal Plasticity
  • Humans
  • Dendritic Spines
  • Animals
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences