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Gonadotropin stimulation protocols in the Norfolk IVF program--1988.

Publication ,  Journal Article
Jones, GS; Muasher, SJ; Liu, HC
Published in: J Steroid Biochem
October 1989

A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood of a good or bad response to a standard protocol. If the FSH is high in relation to LH, the patient will likely be a low responder and/or approaching the menopause. A regime of high-dose pure FSH seems to improve the number of eggs in this group and therefore the pregnancy rate. On the other hand, if the FSH/LH ratio is very low, that is, the patient has a high LH, the patient is generally a high responder and produces many eggs, but in some instances the quality of eggs is suspect, and the pregnancy rate is low in a particular subset of high responders. The use of GnRHa and/or minimal stimulation with FSH or hMG seems to improve the pregnancy rate.

Duke Scholars

Published In

J Steroid Biochem

DOI

ISSN

0022-4731

Publication Date

October 1989

Volume

33

Issue

4B

Start / End Page

823 / 825

Location

England

Related Subject Headings

  • Pregnancy
  • Polycystic Ovary Syndrome
  • Ovulation Induction
  • Menotropins
  • Luteinizing Hormone
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female
 

Citation

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Jones, G. S., Muasher, S. J., & Liu, H. C. (1989). Gonadotropin stimulation protocols in the Norfolk IVF program--1988. J Steroid Biochem, 33(4B), 823–825. https://doi.org/10.1016/0022-4731(89)90500-1
Jones, G. S., S. J. Muasher, and H. C. Liu. “Gonadotropin stimulation protocols in the Norfolk IVF program--1988.J Steroid Biochem 33, no. 4B (October 1989): 823–25. https://doi.org/10.1016/0022-4731(89)90500-1.
Jones GS, Muasher SJ, Liu HC. Gonadotropin stimulation protocols in the Norfolk IVF program--1988. J Steroid Biochem. 1989 Oct;33(4B):823–5.
Jones, G. S., et al. “Gonadotropin stimulation protocols in the Norfolk IVF program--1988.J Steroid Biochem, vol. 33, no. 4B, Oct. 1989, pp. 823–25. Pubmed, doi:10.1016/0022-4731(89)90500-1.
Jones GS, Muasher SJ, Liu HC. Gonadotropin stimulation protocols in the Norfolk IVF program--1988. J Steroid Biochem. 1989 Oct;33(4B):823–825.

Published In

J Steroid Biochem

DOI

ISSN

0022-4731

Publication Date

October 1989

Volume

33

Issue

4B

Start / End Page

823 / 825

Location

England

Related Subject Headings

  • Pregnancy
  • Polycystic Ovary Syndrome
  • Ovulation Induction
  • Menotropins
  • Luteinizing Hormone
  • Humans
  • Follicle Stimulating Hormone
  • Fertilization in Vitro
  • Female