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Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.

Publication ,  Journal Article
Nakata, I; Yamashiro, K; Akagi-Kurashige, Y; Miyake, M; Kumagai, K; Tsujikawa, A; Liu, K; Chen, LJ; Liu, DTL; Lai, TYY; Sakurada, Y; Yeo, IY ...
Published in: Invest Ophthalmol Vis Sci
September 25, 2012

PURPOSE: To evaluate the association of genetic variants at chromosomes 8p21 and 4q12 with the risk of developing AMD and its two main subtypes, choroidal neovascular membrane (CNV) and polypoidal choroidal vasculopathy (PCV), in Asian populations. METHODS: The study population comprised 2360 patients with neovascular AMD (1013 typical AMD-CNV and 1282 PCV), and 3598 controls from four independent cohorts, two of Japanese (n = 4859) and two of Chinese (n = 1099) ethnicity. We performed a meta-analysis in case-control studies of two reported single nucleotide polymorphisms (SNPs) (rs13278062 at TNFRSF10A-LOC389641 on 8p21 and rs1713985 at REST-C4orf14-POLR2B-IGFBP7 on 4q12) by using logistic regression analysis adjusted for age and sex. Subgroup analysis by CNV and PCV subtypes were performed to evaluate the significance of these two variants. RESULTS: The reported association between rs13278062 at 8p21 and neovascular AMD was replicated in this population (P = 1.12 × 10(-4), odds ratio [OR] = 0.79, 95% confidence interval [CI] = 0.70-0.89). However, there was no association of rs1713985 at 4q12 with neovascular AMD, or its two subtypes, typical AMD-CNV and PCV (all P > 0.05). The study sample size had a statistical power of greater than 99% to detect an association of a risk allele with AMD with an OR of 1.30, as reported in the original study of rs1713985 and AMD. CONCLUSIONS: The present results did not replicate the reported association between rs1713985 at 4q12 and neovascular AMD. However, we confirmed the association between rs13278062 at 8p21 and neovascular AMD in Asian populations.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 25, 2012

Volume

53

Issue

10

Start / End Page

6576 / 6581

Location

United States

Related Subject Headings

  • Risk Factors
  • Real-Time Polymerase Chain Reaction
  • Polyps
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Japan
  • Humans
 

Citation

APA
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ICMJE
MLA
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Nakata, I., Yamashiro, K., Akagi-Kurashige, Y., Miyake, M., Kumagai, K., Tsujikawa, A., … Yoshimura, N. (2012). Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. Invest Ophthalmol Vis Sci, 53(10), 6576–6581. https://doi.org/10.1167/iovs.12-10219
Nakata, Isao, Kenji Yamashiro, Yumiko Akagi-Kurashige, Masahiro Miyake, Kyoko Kumagai, Akitaka Tsujikawa, Ke Liu, et al. “Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.Invest Ophthalmol Vis Sci 53, no. 10 (September 25, 2012): 6576–81. https://doi.org/10.1167/iovs.12-10219.
Nakata I, Yamashiro K, Akagi-Kurashige Y, Miyake M, Kumagai K, Tsujikawa A, et al. Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6576–81.
Nakata, Isao, et al. “Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.Invest Ophthalmol Vis Sci, vol. 53, no. 10, Sept. 2012, pp. 6576–81. Pubmed, doi:10.1167/iovs.12-10219.
Nakata I, Yamashiro K, Akagi-Kurashige Y, Miyake M, Kumagai K, Tsujikawa A, Liu K, Chen LJ, Liu DTL, Lai TYY, Sakurada Y, Yoneyama S, Cheng C-Y, Cackett P, Yeo IY, Tay WT, Cornes BK, Vithana EN, Aung T, Matsuo K, Matsuda F, Wong T-Y, Iijima H, Pang CP, Yoshimura N. Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations. Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6576–6581.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 25, 2012

Volume

53

Issue

10

Start / End Page

6576 / 6581

Location

United States

Related Subject Headings

  • Risk Factors
  • Real-Time Polymerase Chain Reaction
  • Polyps
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Japan
  • Humans