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Thiazide diuretic agents and the incidence of hip fracture.

Publication ,  Journal Article
LaCroix, AZ; Wienpahl, J; White, LR; Wallace, RB; Scherr, PA; George, LK; Cornoni-Huntley, J; Ostfeld, AM
Published in: The New England journal of medicine
February 1990

Thiazide diuretic agents lower the urinary excretion of calcium. Their use has been associated with increased bone density, but their role in preventing hip fracture has not been established. We prospectively studied the effect of thiazide diuretic agents on the incidence of hip fracture among 9518 men and women 65 years of age or older residing in three communities. At base line, 24 to 30 percent of the subjects were thiazide users. In the subsequent four years, 242 subjects had hip fractures. The incidence rates of hip fracture were lower among thiazide users than nonusers in each community; the Mantel-Haenszel relative risk of hip fracture, adjusted for community and age, was 0.63 (95 percent confidence interval, 0.46 to 0.86). The protective effect of the use of thiazides was independent of sex, age, impaired mobility, body-mass index, and current and former smoking status; the multivariate adjusted relative risk of hip fracture was 0.68 (95 percent confidence interval, 0.49 to 0.94). Furthermore, the protective effect was specific to thiazide diuretic agents, since there was no association between the use of antihypertensive medications other than thiazides and the risk of hip fracture. These prospective data suggest that in older men and women the use of thiazide diuretic agents is associated with a reduction of approximately one third in the risk of hip fracture.

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Published In

The New England journal of medicine

DOI

EISSN

1533-4406

ISSN

0028-4793

Publication Date

February 1990

Volume

322

Issue

5

Start / End Page

286 / 290

Related Subject Headings

  • Sodium Chloride Symporter Inhibitors
  • Sex Factors
  • Risk Factors
  • Prospective Studies
  • Movement
  • Male
  • Iowa
  • Humans
  • Hip Fractures
  • General & Internal Medicine
 

Citation

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ICMJE
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LaCroix, A. Z., Wienpahl, J., White, L. R., Wallace, R. B., Scherr, P. A., George, L. K., … Ostfeld, A. M. (1990). Thiazide diuretic agents and the incidence of hip fracture. The New England Journal of Medicine, 322(5), 286–290. https://doi.org/10.1056/nejm199002013220502
LaCroix, A. Z., J. Wienpahl, L. R. White, R. B. Wallace, P. A. Scherr, L. K. George, J. Cornoni-Huntley, and A. M. Ostfeld. “Thiazide diuretic agents and the incidence of hip fracture.The New England Journal of Medicine 322, no. 5 (February 1990): 286–90. https://doi.org/10.1056/nejm199002013220502.
LaCroix AZ, Wienpahl J, White LR, Wallace RB, Scherr PA, George LK, et al. Thiazide diuretic agents and the incidence of hip fracture. The New England journal of medicine. 1990 Feb;322(5):286–90.
LaCroix, A. Z., et al. “Thiazide diuretic agents and the incidence of hip fracture.The New England Journal of Medicine, vol. 322, no. 5, Feb. 1990, pp. 286–90. Epmc, doi:10.1056/nejm199002013220502.
LaCroix AZ, Wienpahl J, White LR, Wallace RB, Scherr PA, George LK, Cornoni-Huntley J, Ostfeld AM. Thiazide diuretic agents and the incidence of hip fracture. The New England journal of medicine. 1990 Feb;322(5):286–290.

Published In

The New England journal of medicine

DOI

EISSN

1533-4406

ISSN

0028-4793

Publication Date

February 1990

Volume

322

Issue

5

Start / End Page

286 / 290

Related Subject Headings

  • Sodium Chloride Symporter Inhibitors
  • Sex Factors
  • Risk Factors
  • Prospective Studies
  • Movement
  • Male
  • Iowa
  • Humans
  • Hip Fractures
  • General & Internal Medicine