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Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

Publication ,  Journal Article
Hartz, SM; Short, SE; Saccone, NL; Culverhouse, R; Chen, L; Schwantes-An, T-H; Coon, H; Han, Y; Stephens, SH; Sun, J; Chen, X; Ducci, F ...
Published in: Arch Gen Psychiatry
August 2012

CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.

Duke Scholars

Published In

Arch Gen Psychiatry

DOI

EISSN

1538-3636

Publication Date

August 2012

Volume

69

Issue

8

Start / End Page

854 / 860

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking
  • Severity of Illness Index
  • Receptors, Nicotinic
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Nerve Tissue Proteins
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L., Schwantes-An, T.-H., … Bierut, L. J. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry, 69(8), 854–860. https://doi.org/10.1001/archgenpsychiatry.2012.124

Published In

Arch Gen Psychiatry

DOI

EISSN

1538-3636

Publication Date

August 2012

Volume

69

Issue

8

Start / End Page

854 / 860

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Smoking
  • Severity of Illness Index
  • Receptors, Nicotinic
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Nicotine
  • Nerve Tissue Proteins
  • Male
  • Humans