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Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.

Publication ,  Journal Article
LaBarre, A; Strauss, HC; Scheinman, MM; Evans, GT; Bashore, T; Tiedeman, JS; Wallace, AG
Published in: Circulation
February 1979

The electrophysiologic effects of intravenously administered disopyramide (2 mg/kg) on three parameters of sinus node function were examined in 16 symptomatic patients with sinus node dysfunction. Based on their ECG data before study, patients were subdivided into group A (n = 8), those with sinus pauses and/or sinoatrial (SA) exit block; and group B (n = 8), those with sinus bradycardia. Disopyramide shortened spontaneous cycle length in 10 of 16 patients and lengthened it in six--markedly so (91%) in one patient. Estimated SA conduction time decreased in seven of 14 patients and increased in seven. Two patients developed second degree SA exit block after disopyramide. Maximum sinus node recovery time was prolonged by disopyramide in 11 of 16 patients and markedly so in four. For the group as a whole there was no significant difference in spontaneous cycle length, maximum sinus node recovery time or estimated SA conduction time. P-wave and QRS durations and H-V intervals were significantly lengthened by disopyramide. Marked depression of the three parameters of sinus node function occurred in three group A patients and in one group B patient who had persistent severe sinus bradycardia. These four patients also had secondary pauses after termination of rapid atrial pacing under control conditions. Disopyramide should be administered cautiously to patients with sinus node dysfunction, particularly those with sinus pauses, SA exit block or secondary pauses.

Duke Scholars

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

February 1979

Volume

59

Issue

2

Start / End Page

226 / 235

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia
  • Sinoatrial Node
  • Sinoatrial Block
  • Pyridines
  • Middle Aged
  • Male
  • Infusions, Parenteral
  • Humans
  • Heart Block
 

Citation

APA
Chicago
ICMJE
MLA
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LaBarre, A., Strauss, H. C., Scheinman, M. M., Evans, G. T., Bashore, T., Tiedeman, J. S., & Wallace, A. G. (1979). Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction. Circulation, 59(2), 226–235. https://doi.org/10.1161/01.cir.59.2.226
LaBarre, A., H. C. Strauss, M. M. Scheinman, G. T. Evans, T. Bashore, J. S. Tiedeman, and A. G. Wallace. “Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.Circulation 59, no. 2 (February 1979): 226–35. https://doi.org/10.1161/01.cir.59.2.226.
LaBarre A, Strauss HC, Scheinman MM, Evans GT, Bashore T, Tiedeman JS, et al. Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction. Circulation. 1979 Feb;59(2):226–35.
LaBarre, A., et al. “Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.Circulation, vol. 59, no. 2, Feb. 1979, pp. 226–35. Pubmed, doi:10.1161/01.cir.59.2.226.
LaBarre A, Strauss HC, Scheinman MM, Evans GT, Bashore T, Tiedeman JS, Wallace AG. Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction. Circulation. 1979 Feb;59(2):226–235.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

February 1979

Volume

59

Issue

2

Start / End Page

226 / 235

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia
  • Sinoatrial Node
  • Sinoatrial Block
  • Pyridines
  • Middle Aged
  • Male
  • Infusions, Parenteral
  • Humans
  • Heart Block