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t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.

Publication ,  Journal Article
Silbergeld, EK; Contreras, EQ; Hartung, T; Hirsch, C; Hogberg, H; Jachak, AC; Jordan, W; Landsiedel, R; Morris, J; Patri, A; Pounds, JG ...
Published in: Altex
January 2011

In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information.

Duke Scholars

Published In

Altex

DOI

EISSN

1868-8551

ISSN

1868-596X

Publication Date

January 2011

Volume

28

Issue

3

Start / End Page

236 / 241

Related Subject Headings

  • Zebrafish
  • United States Food and Drug Administration
  • United States
  • Toxicology
  • Toxicity Tests
  • Pharmaceutical Preparations
  • Nanostructures
  • Models, Biological
  • Investigational New Drug Application
  • Caenorhabditis elegans
 

Citation

APA
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Silbergeld, E. K., Contreras, E. Q., Hartung, T., Hirsch, C., Hogberg, H., Jachak, A. C., … Zurlo, J. (2011). t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex, 28(3), 236–241. https://doi.org/10.14573/altex.2011.3.236
Silbergeld, Ellen K., Elizabeth Q. Contreras, Thomas Hartung, Cordula Hirsch, Helena Hogberg, Ashish C. Jachak, William Jordan, et al. “t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.Altex 28, no. 3 (January 2011): 236–41. https://doi.org/10.14573/altex.2011.3.236.
Silbergeld EK, Contreras EQ, Hartung T, Hirsch C, Hogberg H, Jachak AC, et al. t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex. 2011 Jan;28(3):236–41.
Silbergeld, Ellen K., et al. “t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials.Altex, vol. 28, no. 3, Jan. 2011, pp. 236–41. Epmc, doi:10.14573/altex.2011.3.236.
Silbergeld EK, Contreras EQ, Hartung T, Hirsch C, Hogberg H, Jachak AC, Jordan W, Landsiedel R, Morris J, Patri A, Pounds JG, de Vizcaya Ruiz A, Shvedova A, Tanguay R, Tatarazako N, van Vliet E, Walker NJ, Wiesner M, Wilcox N, Zurlo J. t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials. Altex. 2011 Jan;28(3):236–241.
Journal cover image

Published In

Altex

DOI

EISSN

1868-8551

ISSN

1868-596X

Publication Date

January 2011

Volume

28

Issue

3

Start / End Page

236 / 241

Related Subject Headings

  • Zebrafish
  • United States Food and Drug Administration
  • United States
  • Toxicology
  • Toxicity Tests
  • Pharmaceutical Preparations
  • Nanostructures
  • Models, Biological
  • Investigational New Drug Application
  • Caenorhabditis elegans