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Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.

Publication ,  Journal Article
Olsen, CM; Nagle, CM; Whiteman, DC; Ness, R; Pearce, CL; Pike, MC; Rossing, MA; Terry, KL; Wu, AH; Australian Cancer Study (Ovarian Cancer), ...
Published in: Endocr Relat Cancer
April 2013

Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes have not been well defined. As the prevalence of obesity has increased dramatically, and classification of ovarian histology has improved in the last decade, we sought to examine the association in a pooled analysis of recent studies participating in the Ovarian Cancer Association Consortium. We evaluated the association between BMI (recent, maximum and in young adulthood) and ovarian cancer risk using original data from 15 case-control studies (13 548 cases and 17 913 controls). We combined study-specific adjusted odds ratios (ORs) using a random-effects model. We further examined the associations by histological subtype, menopausal status and post-menopausal hormone use. High BMI (all time-points) was associated with increased risk. This was most pronounced for borderline serous (recent BMI: pooled OR=1.24 per 5 kg/m(2); 95% CI 1.18-1.30), invasive endometrioid (1.17; 1.11-1.23) and invasive mucinous (1.19; 1.06-1.32) tumours. There was no association with serous invasive cancer overall (0.98; 0.94-1.02), but increased risks for low-grade serous invasive tumours (1.13, 1.03-1.25) and in pre-menopausal women (1.11; 1.04-1.18). Among post-menopausal women, the associations did not differ between hormone replacement therapy users and non-users. Whilst obesity appears to increase risk of the less common histological subtypes of ovarian cancer, it does not increase risk of high-grade invasive serous cancers, and reducing BMI is therefore unlikely to prevent the majority of ovarian cancer deaths. Other modifiable factors must be identified to control this disease.

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Published In

Endocr Relat Cancer

DOI

EISSN

1479-6821

Publication Date

April 2013

Volume

20

Issue

2

Start / End Page

251 / 262

Location

England

Related Subject Headings

  • Societies, Medical
  • Risk
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Obesity
  • Neoplasm Grading
  • Humans
  • Female
  • Body Mass Index
 

Citation

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Olsen, C. M., Nagle, C. M., Whiteman, D. C., Ness, R., Pearce, C. L., Pike, M. C., … Ovarian Cancer Association Consortium, . (2013). Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer, 20(2), 251–262. https://doi.org/10.1530/ERC-12-0395
Olsen, Catherine M., Christina M. Nagle, David C. Whiteman, Roberta Ness, Celeste Leigh Pearce, Malcolm C. Pike, Mary Anne Rossing, et al. “Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.Endocr Relat Cancer 20, no. 2 (April 2013): 251–62. https://doi.org/10.1530/ERC-12-0395.
Olsen CM, Nagle CM, Whiteman DC, Ness R, Pearce CL, Pike MC, et al. Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer. 2013 Apr;20(2):251–62.
Olsen, Catherine M., et al. “Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium.Endocr Relat Cancer, vol. 20, no. 2, Apr. 2013, pp. 251–62. Pubmed, doi:10.1530/ERC-12-0395.
Olsen CM, Nagle CM, Whiteman DC, Ness R, Pearce CL, Pike MC, Rossing MA, Terry KL, Wu AH, Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Risch HA, Yu H, Doherty JA, Chang-Claude J, Hein R, Nickels S, Wang-Gohrke S, Goodman MT, Carney ME, Matsuno RK, Lurie G, Moysich K, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Vierkant RA, Larson MC, Schildkraut J, Hoyo C, Moorman P, Weber RP, Cramer DW, Vitonis AF, Bandera EV, Olson SH, Rodriguez-Rodriguez L, King M, Brinton LA, Yang H, Garcia-Closas M, Lissowska J, Anton-Culver H, Ziogas A, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Webb PM, Ovarian Cancer Association Consortium. Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocr Relat Cancer. 2013 Apr;20(2):251–262.
Journal cover image

Published In

Endocr Relat Cancer

DOI

EISSN

1479-6821

Publication Date

April 2013

Volume

20

Issue

2

Start / End Page

251 / 262

Location

England

Related Subject Headings

  • Societies, Medical
  • Risk
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Obesity
  • Neoplasm Grading
  • Humans
  • Female
  • Body Mass Index