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Molecular sentinel-on-chip for SERS-based biosensing.

Publication ,  Journal Article
Wang, H-N; Dhawan, A; Du, Y; Batchelor, D; Leonard, DN; Misra, V; Vo-Dinh, T
Published in: Physical chemistry chemical physics : PCCP
April 2013

The development of DNA detection techniques on large-area plasmonics-active platforms is critical for many medical applications such as high-throughput screening, medical diagnosis and systems biology research. Here, we report for the first time a unique "molecular sentinel-on-chip" (MSC) technology for surface-enhanced Raman scattering (SERS)-based DNA detection. This unique approach allows label-free detection of DNA molecules on chips developed on a wafer scale using large area nanofabrication methodologies. To develop plasmonics-active biosensing platforms in a repeatable and reproducible manner, we employed a combination of deep UV lithography, atomic layer deposition, and metal deposition to fabricate triangular-shaped nanowire (TSNW) arrays having controlled sub-10 nm gap nanostructures over an entire 6 inch wafer. The detection of a DNA sequence of the Ki-67 gene, a critical breast cancer biomarker, on the TSNW substrate illustrates the usefulness and potential of the MSC technology as a novel SERS-based DNA detection method.

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Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

April 2013

Volume

15

Issue

16

Start / End Page

6008 / 6015

Related Subject Headings

  • Spectrum Analysis, Raman
  • Silicon
  • Oligonucleotide Probes
  • Oligonucleotide Array Sequence Analysis
  • Nanowires
  • Ki-67 Antigen
  • Humans
  • Female
  • DNA
  • Chemical Physics
 

Citation

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Wang, H.-N., Dhawan, A., Du, Y., Batchelor, D., Leonard, D. N., Misra, V., & Vo-Dinh, T. (2013). Molecular sentinel-on-chip for SERS-based biosensing. Physical Chemistry Chemical Physics : PCCP, 15(16), 6008–6015. https://doi.org/10.1039/c3cp00076a
Wang, Hsin-Neng, Anuj Dhawan, Yan Du, Dale Batchelor, Donovan N. Leonard, Veena Misra, and Tuan Vo-Dinh. “Molecular sentinel-on-chip for SERS-based biosensing.Physical Chemistry Chemical Physics : PCCP 15, no. 16 (April 2013): 6008–15. https://doi.org/10.1039/c3cp00076a.
Wang H-N, Dhawan A, Du Y, Batchelor D, Leonard DN, Misra V, et al. Molecular sentinel-on-chip for SERS-based biosensing. Physical chemistry chemical physics : PCCP. 2013 Apr;15(16):6008–15.
Wang, Hsin-Neng, et al. “Molecular sentinel-on-chip for SERS-based biosensing.Physical Chemistry Chemical Physics : PCCP, vol. 15, no. 16, Apr. 2013, pp. 6008–15. Epmc, doi:10.1039/c3cp00076a.
Wang H-N, Dhawan A, Du Y, Batchelor D, Leonard DN, Misra V, Vo-Dinh T. Molecular sentinel-on-chip for SERS-based biosensing. Physical chemistry chemical physics : PCCP. 2013 Apr;15(16):6008–6015.
Journal cover image

Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

April 2013

Volume

15

Issue

16

Start / End Page

6008 / 6015

Related Subject Headings

  • Spectrum Analysis, Raman
  • Silicon
  • Oligonucleotide Probes
  • Oligonucleotide Array Sequence Analysis
  • Nanowires
  • Ki-67 Antigen
  • Humans
  • Female
  • DNA
  • Chemical Physics