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Effect of vitamin D supplementation on blood pressure in blacks.

Publication ,  Journal Article
Forman, JP; Scott, JB; Ng, K; Drake, BF; Suarez, EG; Hayden, DL; Bennett, GG; Chandler, PD; Hollis, BW; Emmons, KM; Giovannucci, EL; Fuchs, CS ...
Published in: Hypertension (Dallas, Tex. : 1979)
April 2013

Blacks have significantly higher rates of hypertension than whites, and lower circulating levels of 25-hydroxyvitamin D. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks. During 2 winters from 2008 to 2010, 283 blacks (median age, 51 years) were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 international units of cholecalciferol per day. At baseline, 3 months, and 6 months, systolic and diastolic pressure and 25-hydroxyvitamin D were measured. The 3-month follow-up was completed in 250 (88%) participants. The difference in systolic pressure between baseline and 3 months was +1.7 mm Hg for those receiving placebo, -0.66 mm Hg for 1000 U/d, -3.4 mm Hg for 2000 U/d, and -4.0 mm Hg for 4000 U/d of cholecalciferol (-1.4 mm Hg for each additional 1000 U/d of cholecalciferol; P=0.04). For each 1-ng/mL increase in plasma 25-hydroxyvitamin D, there was a significant 0.2-mm Hg reduction in systolic pressure (P=0.02). There was no effect of cholecalciferol supplementation on diastolic pressure (P=0.37). Within an unselected population of blacks, 3 months of oral vitamin D3 supplementation significantly, yet modestly, lowered systolic pressure. Future trials of vitamin D supplementation on blood pressure are needed to confirm these promising results, particularly among blacks, a population for whom vitamin D deficiency may play a more specific mechanistic role in the pathogenesis of hypertension.

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Published In

Hypertension (Dallas, Tex. : 1979)

DOI

EISSN

1524-4563

ISSN

0194-911X

Publication Date

April 2013

Volume

61

Issue

4

Start / End Page

779 / 785

Related Subject Headings

  • Vitamins
  • Treatment Outcome
  • Prospective Studies
  • Prevalence
  • Massachusetts
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Double-Blind Method
  • Dose-Response Relationship, Drug
 

Citation

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Forman, J. P., Scott, J. B., Ng, K., Drake, B. F., Suarez, E. G., Hayden, D. L., … Chan, A. T. (2013). Effect of vitamin D supplementation on blood pressure in blacks. Hypertension (Dallas, Tex. : 1979), 61(4), 779–785. https://doi.org/10.1161/hypertensionaha.111.00659
Forman, John P., Jamil B. Scott, Kimmie Ng, Bettina F. Drake, Elizabeth Gonzalez Suarez, Douglas L. Hayden, Gary G. Bennett, et al. “Effect of vitamin D supplementation on blood pressure in blacks.Hypertension (Dallas, Tex. : 1979) 61, no. 4 (April 2013): 779–85. https://doi.org/10.1161/hypertensionaha.111.00659.
Forman JP, Scott JB, Ng K, Drake BF, Suarez EG, Hayden DL, et al. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension (Dallas, Tex : 1979). 2013 Apr;61(4):779–85.
Forman, John P., et al. “Effect of vitamin D supplementation on blood pressure in blacks.Hypertension (Dallas, Tex. : 1979), vol. 61, no. 4, Apr. 2013, pp. 779–85. Epmc, doi:10.1161/hypertensionaha.111.00659.
Forman JP, Scott JB, Ng K, Drake BF, Suarez EG, Hayden DL, Bennett GG, Chandler PD, Hollis BW, Emmons KM, Giovannucci EL, Fuchs CS, Chan AT. Effect of vitamin D supplementation on blood pressure in blacks. Hypertension (Dallas, Tex : 1979). 2013 Apr;61(4):779–785.

Published In

Hypertension (Dallas, Tex. : 1979)

DOI

EISSN

1524-4563

ISSN

0194-911X

Publication Date

April 2013

Volume

61

Issue

4

Start / End Page

779 / 785

Related Subject Headings

  • Vitamins
  • Treatment Outcome
  • Prospective Studies
  • Prevalence
  • Massachusetts
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Double-Blind Method
  • Dose-Response Relationship, Drug