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Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva.

Publication ,  Journal Article
Izutsu, KT; Menard, TW; Schubert, MM; Ensign, WY; Sullivan, K; Truelove, EL; Thomas, ED
Published in: Lab Invest
March 1985

Graft versus host disease-dependent decreases in salivary IgA levels were sought in labial gland saliva samples from bone marrow transplant recipients. Transplantation-associated, irradiation-related effects were also present, but these could be avoided if analyses were performed at 1 year or later after transplantation. Sampling of minor gland saliva eliminated the possibility of contamination with IgA-rich serum transudates arising from gingival or mucosal pathways which obscured results from previous studies using whole saliva samples. Patients with active extensive clinical disease had significantly depressed levels of salivary IgA. Since labial saliva is a principal source of total salivary IgA, the present findings may explain why patients with graft versus host disease are susceptible to infection via the sinobronchial portal.

Duke Scholars

Published In

Lab Invest

ISSN

0023-6837

Publication Date

March 1985

Volume

52

Issue

3

Start / End Page

292 / 297

Location

United States

Related Subject Headings

  • Time Factors
  • Saliva
  • Pathology
  • Male
  • Immunoglobulin A, Secretory
  • Immunoglobulin A
  • Humans
  • Graft vs Host Disease
  • Female
  • Bone Marrow Transplantation
 

Citation

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Chicago
ICMJE
MLA
NLM
Izutsu, K. T., Menard, T. W., Schubert, M. M., Ensign, W. Y., Sullivan, K., Truelove, E. L., & Thomas, E. D. (1985). Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva. Lab Invest, 52(3), 292–297.
Izutsu, K. T., T. W. Menard, M. M. Schubert, W. Y. Ensign, K. Sullivan, E. L. Truelove, and E. D. Thomas. “Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva.Lab Invest 52, no. 3 (March 1985): 292–97.
Izutsu KT, Menard TW, Schubert MM, Ensign WY, Sullivan K, Truelove EL, et al. Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva. Lab Invest. 1985 Mar;52(3):292–7.
Izutsu KT, Menard TW, Schubert MM, Ensign WY, Sullivan K, Truelove EL, Thomas ED. Graft versus host disease-related secretory immunoglobulin A deficiency in bone marrow transplant recipients. Findings in labial saliva. Lab Invest. 1985 Mar;52(3):292–297.

Published In

Lab Invest

ISSN

0023-6837

Publication Date

March 1985

Volume

52

Issue

3

Start / End Page

292 / 297

Location

United States

Related Subject Headings

  • Time Factors
  • Saliva
  • Pathology
  • Male
  • Immunoglobulin A, Secretory
  • Immunoglobulin A
  • Humans
  • Graft vs Host Disease
  • Female
  • Bone Marrow Transplantation