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Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment.

Publication ,  Journal Article
Storb, R; Prentice, RL; Buckner, CD; Clift, RA; Appelbaum, F; Deeg, J; Doney, K; Hansen, JA; Mason, M; Sanders, JE; Singer, J; Sullivan, KM ...
Published in: N Engl J Med
February 10, 1983

One hundred thirty patients with severe aplastic anemia were conditioned with cyclophosphamide for transplantation of marrow from HLA-identical siblings. The patients were selected for the present analysis according to the criterion of sustained marrow engraftment. Of the 130 patients, 97 are now alive between 1.4 and 11 years (median, 5) after transplantation. Twenty-nine of the thirty-three who died had either acute or chronic graft-versus-host disease (GVHD). Our analysis was directed at identifying factors predicting GVHD and survival after transplantation in patients. Our key findings were that moderately severe to severe acute GVHD had a strong adverse influence on survival; that a protective environment significantly reduced mortality, which corresponded in part to a reduction in and delayed onset of acute GVHD; that refractoriness to random-donor platelet infusions at transplantation adversely influenced survival, particularly among patients with acute GVHD; and that increasing age was associated with increased mortality.

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Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

February 10, 1983

Volume

308

Issue

6

Start / End Page

302 / 307

Location

United States

Related Subject Headings

  • Tissue Donors
  • Prognosis
  • Platelet Transfusion
  • Male
  • Humans
  • Histocompatibility Testing
  • Graft vs Host Reaction
  • General & Internal Medicine
  • Female
  • Environment, Controlled
 

Citation

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Storb, R., Prentice, R. L., Buckner, C. D., Clift, R. A., Appelbaum, F., Deeg, J., … Thomas, E. D. (1983). Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. N Engl J Med, 308(6), 302–307. https://doi.org/10.1056/NEJM198302103080602
Storb, R., R. L. Prentice, C. D. Buckner, R. A. Clift, F. Appelbaum, J. Deeg, K. Doney, et al. “Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment.N Engl J Med 308, no. 6 (February 10, 1983): 302–7. https://doi.org/10.1056/NEJM198302103080602.
Storb, R., et al. “Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment.N Engl J Med, vol. 308, no. 6, Feb. 1983, pp. 302–07. Pubmed, doi:10.1056/NEJM198302103080602.
Storb R, Prentice RL, Buckner CD, Clift RA, Appelbaum F, Deeg J, Doney K, Hansen JA, Mason M, Sanders JE, Singer J, Sullivan KM, Witherspoon RP, Thomas ED. Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. N Engl J Med. 1983 Feb 10;308(6):302–307.
Journal cover image

Published In

N Engl J Med

DOI

ISSN

0028-4793

Publication Date

February 10, 1983

Volume

308

Issue

6

Start / End Page

302 / 307

Location

United States

Related Subject Headings

  • Tissue Donors
  • Prognosis
  • Platelet Transfusion
  • Male
  • Humans
  • Histocompatibility Testing
  • Graft vs Host Reaction
  • General & Internal Medicine
  • Female
  • Environment, Controlled