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Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation.

Publication ,  Journal Article
Sanders, JE; Buckner, CD; Leonard, JM; Sullivan, KM; Witherspoon, RP; Deeg, HJ; Storb, R; Thomas, ED
Published in: Transplantation
September 1983

One hundred thirty-seven patients had gonadal function evaluated 1-11 years after marrow transplantation. All 15 women less than age 26 and three of nine older than age 26 who were treated with 200 mg/kg cyclophosphamide recovered normal gonadotropin levels and menstruation. Five have had five pregnancies resulting in three live births, one spontaneous abortion, and one elective abortion. Three of 38 women who were prepared with 120 mg/kg cyclophosphamide and 920-1200 rad total-body irradiation had normal gonadotropin levels and menstruation. Two had pregnancies resulting in one spontaneous and one elective abortion. Of 31 men prepared with 200 mg/kg cyclophosphamide, 30 had normal luteinizing hormone levels, 20 had normal follicle-stimulating hormone levels, and 10 of 15 had spermatogenesis. Four have fathered five normal children. Thirty-six of 41 men prepared with 120 mg/kg cyclophosphamide and 920-1750 rad total-body irradiation had normal luteinizing hormone levels, ten had normal follicle-stimulating hormone levels, and 2 of 32 studied had spermatogenesis. One has fathered two normal children. It was concluded that cyclophosphamide does not prevent return of normal gonadal function in younger women and in most men. Total-body irradiation prevents return of normal gonadal function in the majority of patients.

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Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

September 1983

Volume

36

Issue

3

Start / End Page

252 / 255

Location

United States

Related Subject Headings

  • Whole-Body Irradiation
  • Surgery
  • Spermatogenesis
  • Pregnancy
  • Menstruation
  • Male
  • Luteinizing Hormone
  • Leukemia
  • Humans
  • Gonads
 

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Chicago
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MLA
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Sanders, J. E., Buckner, C. D., Leonard, J. M., Sullivan, K. M., Witherspoon, R. P., Deeg, H. J., … Thomas, E. D. (1983). Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation, 36(3), 252–255. https://doi.org/10.1097/00007890-198309000-00005
Sanders, J. E., C. D. Buckner, J. M. Leonard, K. M. Sullivan, R. P. Witherspoon, H. J. Deeg, R. Storb, and E. D. Thomas. “Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation.Transplantation 36, no. 3 (September 1983): 252–55. https://doi.org/10.1097/00007890-198309000-00005.
Sanders JE, Buckner CD, Leonard JM, Sullivan KM, Witherspoon RP, Deeg HJ, et al. Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation. 1983 Sep;36(3):252–5.
Sanders, J. E., et al. “Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation.Transplantation, vol. 36, no. 3, Sept. 1983, pp. 252–55. Pubmed, doi:10.1097/00007890-198309000-00005.
Sanders JE, Buckner CD, Leonard JM, Sullivan KM, Witherspoon RP, Deeg HJ, Storb R, Thomas ED. Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation. Transplantation. 1983 Sep;36(3):252–255.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

September 1983

Volume

36

Issue

3

Start / End Page

252 / 255

Location

United States

Related Subject Headings

  • Whole-Body Irradiation
  • Surgery
  • Spermatogenesis
  • Pregnancy
  • Menstruation
  • Male
  • Luteinizing Hormone
  • Leukemia
  • Humans
  • Gonads